TY - JOUR
T1 - Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4
AU - Autieri, Michael V.
AU - Kozak, Christine A.
AU - Cohen, Jeffery A.
AU - Prystowsky, Michael B.
N1 - Funding Information:
This work was supported by National Institutes of Health Award GM-41226 and BRSG 9-526-0522 from the Albert Einstein College of Medicine to M.B.P. and Public Health Service Training Grant CA09140-19 to M.V.A.M.B.P. is the recipient of an American Cancer Society Faculty Research Award. We thank M. Charlene Adamson for technical assistance.
PY - 1995
Y1 - 1995
N2 - The nervous and immune systems share many functional and molecular similarities, including shared surface antigens, secretions of soluble factors, and cross-modulatory effects. We have identified previously a novel mRNA termed F5, which is expressed only in activated T lymphocytes and mature, postmitotic neurons. Tissue specificity and sequence conservation suggest an important function for F5 in T-lymphocyte proliferation and neuronal maturation. The F5 gene product is an evolutionarily conserved, cytoskeletal-associated phosphoprotein. A full-length mouse genomic clone has been isolated. The protein coding region of the F5 gene is approximately 16 kb in length and is composed of 13 coding exons. The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4.
AB - The nervous and immune systems share many functional and molecular similarities, including shared surface antigens, secretions of soluble factors, and cross-modulatory effects. We have identified previously a novel mRNA termed F5, which is expressed only in activated T lymphocytes and mature, postmitotic neurons. Tissue specificity and sequence conservation suggest an important function for F5 in T-lymphocyte proliferation and neuronal maturation. The F5 gene product is an evolutionarily conserved, cytoskeletal-associated phosphoprotein. A full-length mouse genomic clone has been isolated. The protein coding region of the F5 gene is approximately 16 kb in length and is composed of 13 coding exons. The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4.
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U2 - 10.1016/0888-7543(95)80137-B
DO - 10.1016/0888-7543(95)80137-B
M3 - Article
C2 - 7774930
AN - SCOPUS:0028963323
SN - 0888-7543
VL - 25
SP - 282
EP - 284
JO - Genomics
JF - Genomics
IS - 1
ER -