@article{bf333e535882461e9ccd7ca1889bbf02,
title = "Genomic organisation and expression of BCL6 in murine B-cell lymphomas",
abstract = "BCL6 encodes a transcription factor deregulated by chromosomal translocations in human diffuse large cell B lymphomas (DLCL). This study was designed to determine whether Bcl6 might also be involved in lymphomas of mice. BCL6 protein was expressed at high levels in 90% or more of DLCL but not in low grade B lymphomas. Southern hybridisation studies demonstrated altered organisation of Bcl6 in three primary DLCL and the WEHI 231 B-cell lymphoma cell line but not in low grade tumours. Chromosomal painting and fluorescence in situ hybridisation (FISH) analyses of the WEHI 231 metaphase spreads revealed a T(5;16) translocation with Bcl6 on Chromosome 16 at the translocation breakpoint. Deregulated expression of BCL6 is thus likely to contribute to the genesis of DLCL of mice as well as of humans. Copyright (C) 2000 Elsevier Science Ltd.",
keywords = "BCL6, Mouse B-cell lymphoma, Spectral karyotyping, Translocation",
author = "Qi, {Chen Feng} and Mitsuo Hori and Coleman, {Allen E.} and Torrey, {Ted A.} and Lekidelu Taddesse-Heath and Ye, {B. Hilda} and Chattopadhyay, {Sisir K.} and Hartley, {Janet W.} and Morse, {H. C.}",
note = "Funding Information: This work was supported in part by contract NO1-AI-45203 to MA Bioservices, Inc. We thank Drs Florence Bernardin, Jean-Pierre Kerckaert, Alexander Dent and Louis Staudt for probes, and Dr Staudt for helpful discussions. Dr Torgny N. Fredrickson was critical to the histopathologic classifications of the tumours used in these studies. The SKY and FISH analyses were performed in the laboratory of Dr Thomas Reid, NHGRS, NIH. We thank Marilyn Lander for help in the preparation and analysis of the primary lymphoma DNAs and Brenda Rae Marshall for excellent editorial assistance. C.F. Qi provided the concept and design, study materials, analysis and interpretation of data and assembled the data. M. Hori, A. Coleman, T. Torrey, L. Taddesse-Heath, and B.H. Ye provided study materials and assisted with data analyses and interpretation. S.K. Chattioadhyay helped to assemble the data and contributed to analysis and data interpretation. J.W. Hartley provided study materials and technical support. H.C. Morse III contributed to the concept, design, analysis of the data, drafted the paper, provided ciritical revisions, gave final approval and provided administrative support. ",
year = "2000",
month = aug,
doi = "10.1016/S0145-2126(00)00028-X",
language = "English (US)",
volume = "24",
pages = "719--732",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "8",
}
