Genomic organisation and expression of BCL6 in murine B-cell lymphomas

Chen Feng Qi, Mitsuo Hori, Allen E. Coleman, Ted A. Torrey, Lekidelu Taddesse-Heath, B. Hilda Ye, Sisir K. Chattopadhyay, Janet W. Hartley, H. C. Morse

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

BCL6 encodes a transcription factor deregulated by chromosomal translocations in human diffuse large cell B lymphomas (DLCL). This study was designed to determine whether Bcl6 might also be involved in lymphomas of mice. BCL6 protein was expressed at high levels in 90% or more of DLCL but not in low grade B lymphomas. Southern hybridisation studies demonstrated altered organisation of Bcl6 in three primary DLCL and the WEHI 231 B-cell lymphoma cell line but not in low grade tumours. Chromosomal painting and fluorescence in situ hybridisation (FISH) analyses of the WEHI 231 metaphase spreads revealed a T(5;16) translocation with Bcl6 on Chromosome 16 at the translocation breakpoint. Deregulated expression of BCL6 is thus likely to contribute to the genesis of DLCL of mice as well as of humans. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)719-732
Number of pages14
JournalLeukemia Research
Volume24
Issue number8
DOIs
StatePublished - Aug 2000

Keywords

  • BCL6
  • Mouse B-cell lymphoma
  • Spectral karyotyping
  • Translocation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Qi, C. F., Hori, M., Coleman, A. E., Torrey, T. A., Taddesse-Heath, L., Ye, B. H., Chattopadhyay, S. K., Hartley, J. W., & Morse, H. C. (2000). Genomic organisation and expression of BCL6 in murine B-cell lymphomas. Leukemia Research, 24(8), 719-732. https://doi.org/10.1016/S0145-2126(00)00028-X