Genome sequence surveys of Brachiola algerae and Edhazardia aedis reveal microsporidia with low gene densities

Bryony A P Williams, Renny C H Lee, James J. Becnel, Louis M. Weiss, Naomi M. Fast, Patrick J. Keeling

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Microsporidia are well known models of extreme nuclear genome reduction and compaction. The smallest microsporidian genomes have received the most attention, but genomes of different species range in size from 2.3 Mb to 19.5 Mb and the nature of the larger genomes remains unknown. Results: Here we have undertaken genome sequence surveys of two diverse microsporidia, Brachiola algerae and Edhazardia aedis. In both species we find very large intergenic regions, many transposable elements, and a low gene-density, all in contrast to the small, model microsporidian genomes. We also find no recognizable genes that are not also found in other surveyed or sequenced microsporidian genomes. Conclusion: Our results demonstrate that microsporidian genome architecture varies greatly between microsporidia. Much of the genome size difference could be accounted for by non-coding material, such as intergenic spaces and retrotransposons, and this suggests that the forces dictating genome size may vary across the phylum.

Original languageEnglish (US)
Article number200
JournalBMC Genomics
Volume9
DOIs
StatePublished - Apr 29 2008

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Microsporidia
Genome
Genes
Genome Size
Retroelements
Intergenic DNA
DNA Transposable Elements
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genome sequence surveys of Brachiola algerae and Edhazardia aedis reveal microsporidia with low gene densities. / Williams, Bryony A P; Lee, Renny C H; Becnel, James J.; Weiss, Louis M.; Fast, Naomi M.; Keeling, Patrick J.

In: BMC Genomics, Vol. 9, 200, 29.04.2008.

Research output: Contribution to journalArticle

Williams, Bryony A P ; Lee, Renny C H ; Becnel, James J. ; Weiss, Louis M. ; Fast, Naomi M. ; Keeling, Patrick J. / Genome sequence surveys of Brachiola algerae and Edhazardia aedis reveal microsporidia with low gene densities. In: BMC Genomics. 2008 ; Vol. 9.
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