Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-Hodgkin lymphoma

Kathryn Hughes Barry, Yawei Zhang, Qing Lan, Shelia Hoar Zahm, Theodore R. Holford, Brian Leaderer, Peter Boyle, Howard D. Hosgood, Stephen Chanock, Meredith Yeager, Nathaniel Rothman, Tongzhang Zheng

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Using 1996-2000 data among Connecticut women, the authors evaluated whether genetic variation in 4 metabolic genes modifies organic solvent associations with non-Hodgkin lymphoma and 5 major histologic subtypes. Pinteraction values were determined from cross-product terms between dichotomous (ever/never) solvent variables and genotypes at examined loci in unconditional logistic regression models. The false discovery rate method was used to account for multiple comparisons. Overall associations between the chlorinated solvents dichloromethane (odds ratio (OR) = 1.69, 95% confidence interval (CI): 1.06, 2.69), carbon tetrachloride (OR = 2.33, 95% CI: 1.23, 4.40), and methyl chloride (OR = 1.44, 95% CI: 0.94, 2.20) and total non-Hodgkin lymphoma were increased among women TT for rs2070673 in the cytochrome P4502E1 gene, CYP2E1 (dichloromethane: OR = 4.42, 95% CI: 2.03, 9.62; Pinteraction < 0.01; carbon tetrachloride: OR = 5.08, 95% CI: 1.82, 14.15; Pinteraction = 0.04; and methyl chloride: OR = 2.37, 95% CI: 1.24, 4.51; Pinteraction = 0.03). In contrast, no effects of these solvents were observed among TA/AA women. Similar patterns were observed for diffuse large B-cell lymphoma and follicular lymphoma, as well as marginal zone lymphoma for dichloromethane. The weak, nonsignificant overall association between benzene and diffuse large B-cell lymphoma (OR = 1.29, 95% CI: 0.84, 1.98) was increased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95% CI: 1.06, 2.97; Pinteraction = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings.

Original languageEnglish (US)
Pages (from-to)404-413
Number of pages10
JournalAmerican Journal of Epidemiology
Volume173
Issue number4
DOIs
StatePublished - Feb 15 2011
Externally publishedYes

Fingerprint

Occupational Exposure
Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
Genes
Methylene Chloride
Methyl Chloride
Lymphoma, Large B-Cell, Diffuse
Carbon Tetrachloride
Logistic Models
Epoxide Hydrolases
Cytochrome P-450 CYP2E1
Follicular Lymphoma
Cytochromes
Benzene
Sample Size
Lymphoma
Genotype

Keywords

  • genetic predisposition to disease
  • lymphoma
  • metabolism
  • non-Hodgkin
  • occupational exposure
  • polymorphism
  • single nucleotide
  • solvents

ASJC Scopus subject areas

  • Epidemiology

Cite this

Barry, K. H., Zhang, Y., Lan, Q., Zahm, S. H., Holford, T. R., Leaderer, B., ... Zheng, T. (2011). Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-Hodgkin lymphoma. American Journal of Epidemiology, 173(4), 404-413. https://doi.org/10.1093/aje/kwq360

Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-Hodgkin lymphoma. / Barry, Kathryn Hughes; Zhang, Yawei; Lan, Qing; Zahm, Shelia Hoar; Holford, Theodore R.; Leaderer, Brian; Boyle, Peter; Hosgood, Howard D.; Chanock, Stephen; Yeager, Meredith; Rothman, Nathaniel; Zheng, Tongzhang.

In: American Journal of Epidemiology, Vol. 173, No. 4, 15.02.2011, p. 404-413.

Research output: Contribution to journalArticle

Barry, KH, Zhang, Y, Lan, Q, Zahm, SH, Holford, TR, Leaderer, B, Boyle, P, Hosgood, HD, Chanock, S, Yeager, M, Rothman, N & Zheng, T 2011, 'Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-Hodgkin lymphoma', American Journal of Epidemiology, vol. 173, no. 4, pp. 404-413. https://doi.org/10.1093/aje/kwq360
Barry, Kathryn Hughes ; Zhang, Yawei ; Lan, Qing ; Zahm, Shelia Hoar ; Holford, Theodore R. ; Leaderer, Brian ; Boyle, Peter ; Hosgood, Howard D. ; Chanock, Stephen ; Yeager, Meredith ; Rothman, Nathaniel ; Zheng, Tongzhang. / Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-Hodgkin lymphoma. In: American Journal of Epidemiology. 2011 ; Vol. 173, No. 4. pp. 404-413.
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abstract = "Using 1996-2000 data among Connecticut women, the authors evaluated whether genetic variation in 4 metabolic genes modifies organic solvent associations with non-Hodgkin lymphoma and 5 major histologic subtypes. Pinteraction values were determined from cross-product terms between dichotomous (ever/never) solvent variables and genotypes at examined loci in unconditional logistic regression models. The false discovery rate method was used to account for multiple comparisons. Overall associations between the chlorinated solvents dichloromethane (odds ratio (OR) = 1.69, 95{\%} confidence interval (CI): 1.06, 2.69), carbon tetrachloride (OR = 2.33, 95{\%} CI: 1.23, 4.40), and methyl chloride (OR = 1.44, 95{\%} CI: 0.94, 2.20) and total non-Hodgkin lymphoma were increased among women TT for rs2070673 in the cytochrome P4502E1 gene, CYP2E1 (dichloromethane: OR = 4.42, 95{\%} CI: 2.03, 9.62; Pinteraction < 0.01; carbon tetrachloride: OR = 5.08, 95{\%} CI: 1.82, 14.15; Pinteraction = 0.04; and methyl chloride: OR = 2.37, 95{\%} CI: 1.24, 4.51; Pinteraction = 0.03). In contrast, no effects of these solvents were observed among TA/AA women. Similar patterns were observed for diffuse large B-cell lymphoma and follicular lymphoma, as well as marginal zone lymphoma for dichloromethane. The weak, nonsignificant overall association between benzene and diffuse large B-cell lymphoma (OR = 1.29, 95{\%} CI: 0.84, 1.98) was increased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95{\%} CI: 1.06, 2.97; Pinteraction = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings.",
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AU - Leaderer, Brian

AU - Boyle, Peter

AU - Hosgood, Howard D.

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