Genetic screening of relatives of decedents experiencing sudden unexpected death: medical examiner’s office referrals to a multi-disciplinary cardiogenetics program

Tamar Siskind, Nori Williams, Monisha Sebastin, Robert Marion, Thomas V. McDonald, Christine Walsh, Barbara Sampson, Yingying Tang, Bradley C. Clark

Research output: Contribution to journalArticlepeer-review

Abstract

Currently, no standardized system exists for evaluating and testing at-risk family members of decedents with abnormal post-mortem genetic testing in cases of sudden unexpected death (SUD). The goal of this study was to evaluate the outcomes of referrals made by an urban medical examiner’s office to a multi-disciplinary cardiogenetics clinic. Relatives of decedents with pathogenic/likely pathogenic (P/LP) variants or variants of unknown significance (VUS) in genes known to be associated with cardiomyopathies and/or arrhythmias were identified by the New York City Office of Chief Medical Examiner and referred to the Cardiogenetics Clinic at Montefiore Medical Center. Familial referrals of 15 decedents (median 15 years, range 2 days to 57 years) were evaluated. Variants in 13 genes were identified among decedents (9 arrhythmia, 5 cardiomyopathy). P/LP variants were identified in both arrhythmia (RYR2, SCN5A) and cardiomyopathy syndrome (MYBPC3 (2), MYH7) genes. Thirty-two family members were referred, and 14 variants were detected. One pathogenic (MYBPC3) and two likely pathogenic (RYR2, MYH7) mutations were identified. Referral of at-risk family members of decedents who experienced SUD based on informative post-mortem genetic testing for cardiac and genetic evaluation is warranted, as family studies help to reclassify variants and prevent additional sudden death.

Original languageEnglish (US)
Pages (from-to)629-639
Number of pages11
JournalJournal of Community Genetics
Volume13
Issue number6
DOIs
StateAccepted/In press - 2022

Keywords

  • Cardiogenetics
  • Cascade genetic screening
  • Molecular autopsy
  • Sudden cardiac death

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Genetic screening of relatives of decedents experiencing sudden unexpected death: medical examiner’s office referrals to a multi-disciplinary cardiogenetics program'. Together they form a unique fingerprint.

Cite this