Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry

Kimberly J. Reidy, Rebecca Hjorten, Rulan S. Parekh

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Purpose of review Understanding the genetic risk of APOL1 in children and young adults is important given the lifetime risk of hypertension and kidney disease among children of African descent. We review recent epidemiologic and biologic findings on the effects of APOL1 and kidney disease. Recent findings APOL1 in children and young adults is associated with hypertension, albuminuria and more rapid decline in kidney function and progression to end-stage kidney disease, especially among those with glomerular causes of kidney disease, and those affected by sickle cell disease or HIV. There are conflicting data on the APOL1 association with cardiovascular disease in children and young adults. APOL1 functions as part of the innate immune system. Podocyte expression of APOL1 likely contributes to the development of kidney disease. In cell culture and model organisms, APOL1 expression disrupts autophagic and ion flux, leads to defects in mitochondrial respiration and induces cell death. Summary APOL1 explains almost 70% of the excess risk of kidney disease in those of African descent, and is common in children with glomerular disease. An evolving understanding of the pathogenesis of APOL1-mediated kidney damage may aid in personalized medicine approaches to APOL1 attributable kidney disease.

Original languageEnglish (US)
Pages (from-to)252-259
Number of pages8
JournalCurrent Opinion in Pediatrics
Volume30
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Kidney Diseases
Young Adult
Hypertension
Kidney
Podocytes
Precision Medicine
Albuminuria
Sickle Cell Anemia
Chronic Kidney Failure
Immune System
Respiration
Cell Death
Cardiovascular Diseases
Cell Culture Techniques
HIV
Ions

Keywords

  • APOL1
  • children
  • end-stage renal disease
  • focal segmental glomerulosclerosis
  • genetics
  • kidney disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry. / Reidy, Kimberly J.; Hjorten, Rebecca; Parekh, Rulan S.

In: Current Opinion in Pediatrics, Vol. 30, No. 2, 01.04.2018, p. 252-259.

Research output: Contribution to journalReview article

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