Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

Xiuli Bi, Chang Tong, Ashley Dockendorff, Laura Bancroft, Lindsay Gallagher, Grace Guzman, Renato V. Iozzo, Leonard H. Augenlicht, Wancai Yang

Research output: Contribution to journalArticle

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Abstract

Decorin is a member of the small leucine-rich proteoglycan gene family and plays an important role in suppressing cancer cell growth and metastasis. To elucidate the importance of decorin in intestinal carcinogenesis, a decorin-deficient (Dcn-/-) mouse model was employed. We found that targeted inactivation of decorin was sufficient to cause intestinal tumor formation with 30% of the Dcn-/- mice developing intestinal tumors with no other chemical or genetic initiation. Moreover, a high-risk diet amplified and accelerated the tumors initiated by decorin deficiency. Further, tumorigenesis in Dcn-/- mice was associated with disruption of intestinal maturation, including decreased cell differentiation and increased proliferation, which were linked to the downregulation of p21WAF1/cip1, p27kip1, intestinal trefoil factor and E-cadherin and to the upregulation of β-catenin signaling. In addition, we found that decorin was highly expressed in the differentiated area of human normal colonic mucosa, but was dramatically reduced in paired colorectal cancer tissues. Taken together, our data demonstrate that decorin acts as a tumor suppressor gene and plays an important role in the maintenance of cell maturation and therefore homeostasis in the intestinal tract.

Original languageEnglish (US)
Pages (from-to)1435-1440
Number of pages6
JournalCarcinogenesis
Volume29
Issue number7
DOIs
StatePublished - 2008

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Decorin
Neoplasms
Carcinogenesis
Catenins
Cadherins
Tumor Suppressor Genes
Cell Differentiation
Colorectal Neoplasms
Mucous Membrane
Homeostasis
Up-Regulation
Down-Regulation
Maintenance
Neoplasm Metastasis
Diet

ASJC Scopus subject areas

  • Cancer Research

Cite this

Bi, X., Tong, C., Dockendorff, A., Bancroft, L., Gallagher, L., Guzman, G., ... Yang, W. (2008). Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis, 29(7), 1435-1440. https://doi.org/10.1093/carcin/bgn141

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. / Bi, Xiuli; Tong, Chang; Dockendorff, Ashley; Bancroft, Laura; Gallagher, Lindsay; Guzman, Grace; Iozzo, Renato V.; Augenlicht, Leonard H.; Yang, Wancai.

In: Carcinogenesis, Vol. 29, No. 7, 2008, p. 1435-1440.

Research output: Contribution to journalArticle

Bi, X, Tong, C, Dockendorff, A, Bancroft, L, Gallagher, L, Guzman, G, Iozzo, RV, Augenlicht, LH & Yang, W 2008, 'Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation', Carcinogenesis, vol. 29, no. 7, pp. 1435-1440. https://doi.org/10.1093/carcin/bgn141
Bi, Xiuli ; Tong, Chang ; Dockendorff, Ashley ; Bancroft, Laura ; Gallagher, Lindsay ; Guzman, Grace ; Iozzo, Renato V. ; Augenlicht, Leonard H. ; Yang, Wancai. / Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. In: Carcinogenesis. 2008 ; Vol. 29, No. 7. pp. 1435-1440.
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