Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Isabelle Eude-le Parco; Gaëlle Gendronneau; Tien Dang; Delphine Delacour; Victor I. Thijssen; Winfried Edelmann; Michel Peuchmaur; Françoise Poirier

doi:10.1093/glycob/cwn105

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Isabelle Eude-le Parco, Gaëlle Gendronneau, Tien Dang, Delphine Delacour, Victor I. Thijssen, Winfried Edelmann, Michel Peuchmaur, Françoise Poirier

Cell Biology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The galectin family of β-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null mutation (galectin-3^-/-) into mouse lines genetically programmed to develop cancers. We used two mouse models of human intestinal cancer, the Apc^Min and Apc^1638N lines, to study tumor initiation and tumor progression. We also crossed the galectin- 3^-/- mice with PyMT transgenic animals, a model in which primary mammary gland tumors give rise to lung metastases at high frequency. Unexpectedly, we show that the absence of galectin-3 does not affect the evolution of the disease in any of these three situations.

Original language	English (US)
Pages (from-to)	68-75
Number of pages	8
Journal	Glycobiology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1093/glycob/cwn105
State	Published - 2009

Keywords

Apc mutations
Galectin-3 knock-out mice
Metastasis
PyMT transgenic
Tumor progression

ASJC Scopus subject areas

Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/glycob/cwn105

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title = "Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice",

abstract = "The galectin family of β-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null mutation (galectin-3-/-) into mouse lines genetically programmed to develop cancers. We used two mouse models of human intestinal cancer, the ApcMin and Apc1638N lines, to study tumor initiation and tumor progression. We also crossed the galectin- 3-/- mice with PyMT transgenic animals, a model in which primary mammary gland tumors give rise to lung metastases at high frequency. Unexpectedly, we show that the absence of galectin-3 does not affect the evolution of the disease in any of these three situations.",

keywords = "Apc mutations, Galectin-3 knock-out mice, Metastasis, PyMT transgenic, Tumor progression",

author = "{Eude-le Parco}, Isabelle and Ga{\"e}lle Gendronneau and Tien Dang and Delphine Delacour and Thijssen, {Victor I.} and Winfried Edelmann and Michel Peuchmaur and Fran{\c c}oise Poirier",

note = "Funding Information: GEFLUC (Groupement des entreprises francaises dans la lutte contre le cancer); the Ligue contre le cancer (comit{\'e} de Paris); the Association pour la Recherche sur le Cancer (postdoctoral fellowship to I.E.L); and the Fondation de la Recherche Medi-cale (postdoctoral fellowship to D.D.).",

year = "2009",

doi = "10.1093/glycob/cwn105",

language = "English (US)",

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pages = "68--75",

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T1 - Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

AU - Eude-le Parco, Isabelle

AU - Gendronneau, Gaëlle

AU - Dang, Tien

AU - Delacour, Delphine

AU - Thijssen, Victor I.

AU - Edelmann, Winfried

AU - Peuchmaur, Michel

AU - Poirier, Françoise

N1 - Funding Information: GEFLUC (Groupement des entreprises francaises dans la lutte contre le cancer); the Ligue contre le cancer (comité de Paris); the Association pour la Recherche sur le Cancer (postdoctoral fellowship to I.E.L); and the Fondation de la Recherche Medi-cale (postdoctoral fellowship to D.D.).

PY - 2009

Y1 - 2009

N2 - The galectin family of β-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null mutation (galectin-3-/-) into mouse lines genetically programmed to develop cancers. We used two mouse models of human intestinal cancer, the ApcMin and Apc1638N lines, to study tumor initiation and tumor progression. We also crossed the galectin- 3-/- mice with PyMT transgenic animals, a model in which primary mammary gland tumors give rise to lung metastases at high frequency. Unexpectedly, we show that the absence of galectin-3 does not affect the evolution of the disease in any of these three situations.

AB - The galectin family of β-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null mutation (galectin-3-/-) into mouse lines genetically programmed to develop cancers. We used two mouse models of human intestinal cancer, the ApcMin and Apc1638N lines, to study tumor initiation and tumor progression. We also crossed the galectin- 3-/- mice with PyMT transgenic animals, a model in which primary mammary gland tumors give rise to lung metastases at high frequency. Unexpectedly, we show that the absence of galectin-3 does not affect the evolution of the disease in any of these three situations.

KW - Apc mutations

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KW - Metastasis

KW - PyMT transgenic

KW - Tumor progression

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Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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