Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Isabelle Eude-le Parco, Gaëlle Gendronneau, Tien Dang, Delphine Delacour, Victor I. Thijssen, Winfried Edelmann, Michel Peuchmaur, Françoise Poirier

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The galectin family of β-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null mutation (galectin-3-/-) into mouse lines genetically programmed to develop cancers. We used two mouse models of human intestinal cancer, the ApcMin and Apc1638N lines, to study tumor initiation and tumor progression. We also crossed the galectin- 3-/- mice with PyMT transgenic animals, a model in which primary mammary gland tumors give rise to lung metastases at high frequency. Unexpectedly, we show that the absence of galectin-3 does not affect the evolution of the disease in any of these three situations.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalGlycobiology
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Apc mutations
  • Galectin-3 knock-out mice
  • Metastasis
  • PyMT transgenic
  • Tumor progression

ASJC Scopus subject areas

  • Biochemistry

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    Eude-le Parco, I., Gendronneau, G., Dang, T., Delacour, D., Thijssen, V. I., Edelmann, W., Peuchmaur, M., & Poirier, F. (2009). Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice. Glycobiology, 19(1), 68-75. https://doi.org/10.1093/glycob/cwn105