Genetic analysis of nonalcoholic fatty liver disease within a caribbean–hispanic population

Deborah Edelman, Harmit S. Kalia, Maria Delio, Mustafa Alani, Karthik Krishnamurthy, Mortadha Abd, Adam J. Auton, Tao Wang, Allan W. Wolkoff, Bernice E. Morrow

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We explored potential genetic risk factors implicated in nonalcoholic fatty liver disease (NAFLD) within a Caribbean–Hispanic population in New York City. A total of 316 individuals including 40 subjects with biopsy-proven NAFLD, 24 ethnically matched non-NAFLD controls, and a 252 ethnically mixed random sampling of Bronx County, New York were analyzed. Genotype analysis was performed to determine allelic frequencies of 74 known single-nucleotide polymorphisms (SNPs) associated with NAFLD risk based on previous genome-wide association study (GWAS) and candidate gene studies. Additionally, the entire coding region of PNPLA3, a gene showing the strongest association to NAFLD was subjected to Sanger sequencing. Results suggest that both rare and common DNA variations in PNPLA3 and SAMM50 may be correlated with NAFLD in this small population study, while common DNA variations in CHUK and ERLIN1, may have a protective interaction. Common SNPs in ENPP1 and ABCC2 have suggestive association with fatty liver, but with less compelling significance. In conclusion, Hispanic patients of Caribbean ancestry may have different interactions with NAFLD genetic modifiers; therefore, further investigation with a larger sample size, into this Caribbean–Hispanic population is warranted.

Original languageEnglish (US)
Pages (from-to)558-569
Number of pages12
JournalMolecular Genetics and Genomic Medicine
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2015

Keywords

  • ABCC2
  • CHUK
  • ENPP1
  • ERLIN1
  • Fatty Liver
  • Gene
  • Hispanic population
  • Liver genetics
  • NAFLD
  • NASH
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • PNPLA3
  • Polymorphism
  • SAMM50

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Genetic analysis of nonalcoholic fatty liver disease within a caribbean–hispanic population'. Together they form a unique fingerprint.

  • Cite this