Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

Milena Botelho Pereira Soares, Ricardo Santana De Lima, Leonardo Lima Rocha, Juliana Fraga Vasconcelos, Silvia Regina Rogatto, Ricardo Ribeiro Dos Santos, Sanda Iacobas, Regina Coeli Goldenberg, Dumitru Andrei Iacobas, Herbert Bernard Tanowitz, Antonio Carlos Campos De Carvalho, David C. Spray

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease.

Original languageEnglish (US)
Pages (from-to)416-426
Number of pages11
JournalJournal of Infectious Diseases
Volume202
Issue number3
DOIs
StatePublished - Aug 1 2010

Fingerprint

Myocarditis
Cardiomyopathies
Fibrosis
Gene Expression
Protein-Lysine 6-Oxidase
Cathepsins
Tissue Inhibitor of Metalloproteinase-1
Chagas Disease
Trypanosoma cruzi
Microarray Analysis
Major Histocompatibility Complex
Chemokines
Extracellular Matrix
Chronic Disease
Up-Regulation
Heart Failure
Genes

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Medicine(all)

Cite this

Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. / Soares, Milena Botelho Pereira; De Lima, Ricardo Santana; Rocha, Leonardo Lima; Vasconcelos, Juliana Fraga; Rogatto, Silvia Regina; Dos Santos, Ricardo Ribeiro; Iacobas, Sanda; Goldenberg, Regina Coeli; Iacobas, Dumitru Andrei; Tanowitz, Herbert Bernard; De Carvalho, Antonio Carlos Campos; Spray, David C.

In: Journal of Infectious Diseases, Vol. 202, No. 3, 01.08.2010, p. 416-426.

Research output: Contribution to journalArticle

Soares, MBP, De Lima, RS, Rocha, LL, Vasconcelos, JF, Rogatto, SR, Dos Santos, RR, Iacobas, S, Goldenberg, RC, Iacobas, DA, Tanowitz, HB, De Carvalho, ACC & Spray, DC 2010, 'Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy', Journal of Infectious Diseases, vol. 202, no. 3, pp. 416-426. https://doi.org/10.1086/653481
Soares, Milena Botelho Pereira ; De Lima, Ricardo Santana ; Rocha, Leonardo Lima ; Vasconcelos, Juliana Fraga ; Rogatto, Silvia Regina ; Dos Santos, Ricardo Ribeiro ; Iacobas, Sanda ; Goldenberg, Regina Coeli ; Iacobas, Dumitru Andrei ; Tanowitz, Herbert Bernard ; De Carvalho, Antonio Carlos Campos ; Spray, David C. / Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. In: Journal of Infectious Diseases. 2010 ; Vol. 202, No. 3. pp. 416-426.
@article{380787a76f81410e95fa3fad43060740,
title = "Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy",
abstract = "Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30{\%} of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12{\%} of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease.",
author = "Soares, {Milena Botelho Pereira} and {De Lima}, {Ricardo Santana} and Rocha, {Leonardo Lima} and Vasconcelos, {Juliana Fraga} and Rogatto, {Silvia Regina} and {Dos Santos}, {Ricardo Ribeiro} and Sanda Iacobas and Goldenberg, {Regina Coeli} and Iacobas, {Dumitru Andrei} and Tanowitz, {Herbert Bernard} and {De Carvalho}, {Antonio Carlos Campos} and Spray, {David C.}",
year = "2010",
month = "8",
day = "1",
doi = "10.1086/653481",
language = "English (US)",
volume = "202",
pages = "416--426",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

AU - Soares, Milena Botelho Pereira

AU - De Lima, Ricardo Santana

AU - Rocha, Leonardo Lima

AU - Vasconcelos, Juliana Fraga

AU - Rogatto, Silvia Regina

AU - Dos Santos, Ricardo Ribeiro

AU - Iacobas, Sanda

AU - Goldenberg, Regina Coeli

AU - Iacobas, Dumitru Andrei

AU - Tanowitz, Herbert Bernard

AU - De Carvalho, Antonio Carlos Campos

AU - Spray, David C.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease.

AB - Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease.

UR - http://www.scopus.com/inward/record.url?scp=77954738641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954738641&partnerID=8YFLogxK

U2 - 10.1086/653481

DO - 10.1086/653481

M3 - Article

VL - 202

SP - 416

EP - 426

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -