Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

Milena Botelho Pereira Soares, Ricardo Santana De Lima, Leonardo Lima Rocha, Juliana Fraga Vasconcelos, Silvia Regina Rogatto, Ricardo Ribeiro Dos Santos, Sanda Iacobas, Regina Coeli Goldenberg, Dumitru Andrei Iacobas, Herbert Bernard Tanowitz, Antonio Carlos Campos De Carvalho, David Conover Spray

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease.

Original languageEnglish (US)
Pages (from-to)416-426
Number of pages11
JournalJournal of Infectious Diseases
Volume202
Issue number3
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Soares, M. B. P., De Lima, R. S., Rocha, L. L., Vasconcelos, J. F., Rogatto, S. R., Dos Santos, R. R., Iacobas, S., Goldenberg, R. C., Iacobas, D. A., Tanowitz, H. B., De Carvalho, A. C. C., & Spray, D. C. (2010). Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. Journal of Infectious Diseases, 202(3), 416-426. https://doi.org/10.1086/653481