Gender differences in melanoma prognostic factors

Jessica Mounessa Farahi, Melissa Fazzari, Taylor Braunberger, Joseph V. Caravaglio, Alexandra Kretowicz, Keith Wells, Robert P. Dellavalle, David Norris, Theodore Alkousakis

Research output: Contribution to journalArticle

Abstract

Background: Although previous studies identify gender differences in melanoma, limited research on the phenomenon exists. Methods: In this retrospective chart review, 1,156 adults diagnosed with melanoma, between 2006-2016, at the University of Colorado were included. Breslow depth, mitotic rate, ulceration status, and location were extracted from charts between March and August 2016. Cochran-Armitage trend tests and cumulative logistic regression were used to examine the association between gender and Breslow depth, univariately and after adjusting for potential confounders. Results: In univariate analysis, males were significantly more likely to present with lesions with higher Breslow depths (p for trend=0.005). In models adjusted for age, melanoma subtype, and location, males were marginally more likely to present with lesions with higher Breslow depths (cumulative OR: 1.261, 95% CI: 0.988-1.611, p=0.060). Males were also marginally more likely to present with lesions with higher mitotic rates, after further adjustments for all other prognostic factors (cumulative OR: 1.244, 95% CI: 0.979-1.580, p=0.074). Limitations: This was a retrospective single-institution study. Conclusion: Differences in mitotic rates among melanomas in males versus females, even after adjustments for all other prognostic factors, suggests that biological differences may contribute to the female prognosis advantage.

Original languageEnglish (US)
Article number2
JournalDermatology Online Journal
Volume24
Issue number4
StatePublished - Apr 2018
Externally publishedYes

Keywords

  • Breslow depth
  • Gender
  • Malignant melanoma
  • Metastasis
  • Mitotic rate
  • Prognosis
  • Ulceration

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Farahi, J. M., Fazzari, M., Braunberger, T., Caravaglio, J. V., Kretowicz, A., Wells, K., Dellavalle, R. P., Norris, D., & Alkousakis, T. (2018). Gender differences in melanoma prognostic factors. Dermatology Online Journal, 24(4), [2].