Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma

Samuel H. Sigal, Scott H. Saul, Herbert E. Auerbach, Edward Raffensperger, Jeffrey A. Kant, John J. Brooks

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The nature of gastric infiltrates consisting primarily of benign-appearing small lymphocytes is at present a controversial issue. Earlier reports of gastric lymphoma developing in gastric pseudolymphoma and more recent immunohistochemical studies demonstrating monoclonal B-cell populations in pseudolymphoma suggest that at least some cases represent low-grade lymphomas or clonal precursor lesions that may develop into lymphoma. Observations of a small lymphocytic infiltrate arising in the region of a gastric ulcer that lacked definitive morphologic evidence of malignancy (lymphoma) but was clearly a monoclonal B-cell proliferation by immunohistochemical and gene rearrangement studies support the notion that some gastric lymphoproliferative lesions that histologically have been called pseudolymphomas may include one or more clonal lymphoid expansions. A histopathologic/molecular model suggesting a potential pathway for the development of morphologically recognizable lymphoma from benign-appearing small lymphocytic infiltrates is presented, and the concept that for a variety of lymphoid proliferations clonality and malignancy may not be synonymous is discussed.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalGastroenterology
Volume97
Issue number1
StatePublished - 1989
Externally publishedYes

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Pseudolymphoma
Immunoglobulin Genes
Gene Rearrangement
Lymphoma
Stomach
B-Lymphocytes
Molecular Models
Stomach Ulcer
Non-Hodgkin's Lymphoma
Neoplasms
Cell Proliferation
Lymphocytes
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sigal, S. H., Saul, S. H., Auerbach, H. E., Raffensperger, E., Kant, J. A., & Brooks, J. J. (1989). Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma. Gastroenterology, 97(1), 195-201.

Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma. / Sigal, Samuel H.; Saul, Scott H.; Auerbach, Herbert E.; Raffensperger, Edward; Kant, Jeffrey A.; Brooks, John J.

In: Gastroenterology, Vol. 97, No. 1, 1989, p. 195-201.

Research output: Contribution to journalArticle

Sigal, SH, Saul, SH, Auerbach, HE, Raffensperger, E, Kant, JA & Brooks, JJ 1989, 'Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma', Gastroenterology, vol. 97, no. 1, pp. 195-201.
Sigal, Samuel H. ; Saul, Scott H. ; Auerbach, Herbert E. ; Raffensperger, Edward ; Kant, Jeffrey A. ; Brooks, John J. / Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma. In: Gastroenterology. 1989 ; Vol. 97, No. 1. pp. 195-201.
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