Abstract
Gap junctions in the nervous system fulfill vital functions of signal transmission and metabolite delivery and buffering. Between neurons, gap junctions form electrotonic synapses providing rapid bidirectional relay that is essential for rapid and synchronous activities. Between glial cells, gap junctions provide a route for long-range intercellular calcium signaling, as well as delivery of glucose and buffering of potassium ions. A family of connexin proteins comprises gap junctions with cell-specific expression, and mutations in the genes that encode connexins are responsible for a number of neurological diseases including the X-linked form of Charcot-Marie-Tooth disease, hereditary nonsyndromic deafness, and oculodentodigital dysplasia.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of the Neurological Sciences |
| Publisher | Elsevier Inc. |
| Pages | 402-408 |
| Number of pages | 7 |
| ISBN (Electronic) | 9780123851574 |
| ISBN (Print) | 9780123851581 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- Connexin
- Coupling
- Cx32
- Cx36
- Cx43
- Cx47
- Electrical synapse
- Glia
- Neurons
- Pannexins
ASJC Scopus subject areas
- Medicine(all)
Cite this
Gap Junctions in the Nervous System. / Spray, David C.; Scemes, E.; Dermietzel, R.
Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014. p. 402-408.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Gap Junctions in the Nervous System
AU - Spray, David C.
AU - Scemes, E.
AU - Dermietzel, R.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Gap junctions in the nervous system fulfill vital functions of signal transmission and metabolite delivery and buffering. Between neurons, gap junctions form electrotonic synapses providing rapid bidirectional relay that is essential for rapid and synchronous activities. Between glial cells, gap junctions provide a route for long-range intercellular calcium signaling, as well as delivery of glucose and buffering of potassium ions. A family of connexin proteins comprises gap junctions with cell-specific expression, and mutations in the genes that encode connexins are responsible for a number of neurological diseases including the X-linked form of Charcot-Marie-Tooth disease, hereditary nonsyndromic deafness, and oculodentodigital dysplasia.
AB - Gap junctions in the nervous system fulfill vital functions of signal transmission and metabolite delivery and buffering. Between neurons, gap junctions form electrotonic synapses providing rapid bidirectional relay that is essential for rapid and synchronous activities. Between glial cells, gap junctions provide a route for long-range intercellular calcium signaling, as well as delivery of glucose and buffering of potassium ions. A family of connexin proteins comprises gap junctions with cell-specific expression, and mutations in the genes that encode connexins are responsible for a number of neurological diseases including the X-linked form of Charcot-Marie-Tooth disease, hereditary nonsyndromic deafness, and oculodentodigital dysplasia.
KW - Connexin
KW - Coupling
KW - Cx32
KW - Cx36
KW - Cx43
KW - Cx47
KW - Electrical synapse
KW - Glia
KW - Neurons
KW - Pannexins
UR - http://www.scopus.com/inward/record.url?scp=85043273414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043273414&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-385157-4.00058-0
DO - 10.1016/B978-0-12-385157-4.00058-0
M3 - Chapter
AN - SCOPUS:85043273414
SN - 9780123851581
SP - 402
EP - 408
BT - Encyclopedia of the Neurological Sciences
PB - Elsevier Inc.
ER -