Gap Junctions in the Nervous System

David C. Spray; E. Scemes; R. Dermietzel

doi:10.1016/B978-0-12-385157-4.00058-0

Gap Junctions in the Nervous System

David C. Spray, E. Scemes, R. Dermietzel

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Gap junctions in the nervous system fulfill vital functions of signal transmission and metabolite delivery and buffering. Between neurons, gap junctions form electrotonic synapses providing rapid bidirectional relay that is essential for rapid and synchronous activities. Between glial cells, gap junctions provide a route for long-range intercellular calcium signaling, as well as delivery of glucose and buffering of potassium ions. A family of connexin proteins comprises gap junctions with cell-specific expression, and mutations in the genes that encode connexins are responsible for a number of neurological diseases including the X-linked form of Charcot-Marie-Tooth disease, hereditary nonsyndromic deafness, and oculodentodigital dysplasia.

Original language	English (US)
Title of host publication	Encyclopedia of the Neurological Sciences
Publisher	Elsevier Inc.
Pages	402-408
Number of pages	7
ISBN (Electronic)	9780123851574
ISBN (Print)	9780123851581
DOIs	https://doi.org/10.1016/B978-0-12-385157-4.00058-0
State	Published - Jan 1 2014

Keywords

Connexin
Coupling
Cx32
Cx36
Cx43
Cx47
Electrical synapse
Glia
Neurons
Pannexins

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-385157-4.00058-0

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Spray, D. C., Scemes, E., & Dermietzel, R. (2014). Gap Junctions in the Nervous System. In Encyclopedia of the Neurological Sciences (pp. 402-408). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00058-0

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