Gap junctions as electrical synapses

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Gap junctions are the morphological substrate of one class of electrical synapse. The history of the debate on electrical vs. chemical transmission is instructive. One lesson is that Occam's razor sometimes cuts too deep; the nervous system does its operations in a number of different ways and a unitarian approach can lead one astray. Electrical synapses can do many things that chemical synapses can do, and do them just as slowly. More intriguing are the modulatory actions that chemical synapses can have on electrical synapses. Voltage dependence provides an important window on structure function relations of the connexins, even where the dependence may have no physiological role. The new molecular approaches will greatly advance our knowledge of where gap junctions occur and permit experimental manipulation with high specificity.

Original languageEnglish (US)
Pages (from-to)349-366
Number of pages18
JournalJournal of Neurocytology
Volume26
Issue number6
DOIs
StatePublished - 1997

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Electrical Synapses
Gap Junctions
Synapses
Pharmacologic Actions
Connexins
Nervous System
History

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Cell Biology
  • Histology

Cite this

Gap junctions as electrical synapses. / Bennett, Michael V. L.

In: Journal of Neurocytology, Vol. 26, No. 6, 1997, p. 349-366.

Research output: Contribution to journalArticle

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