Gap junction-mediated electrical transmission

Regulatory mechanisms and plasticity

Alberto E. Pereda, Sebastian Curti, Gregory Hoge, Roger Cachope, Carmen E. Flores, John E. Rash

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The term synapse applies to cellular specializations that articulate the processing of information within neural circuits by providing a mechanism for the transfer of information between two different neurons. There are two main modalities of synaptic transmission: chemical and electrical. While most efforts have been dedicated to the understanding of the properties and modifiability of chemical transmission, less is still known regarding the plastic properties of electrical synapses, whose structural correlate is the gap junction. A wealth of data indicates that, rather than passive intercellular channels, electrical synapses are more dynamic and modifiable than was generally perceived. This article will discuss the factors determining the strength of electrical transmission and review current evidence demonstrating its dynamic properties. Like their chemical counterparts, electrical synapses can also be plastic and modifiable. This article is part of a Special Issue entitled: The Communicating junctions, roles and dysfunctions.

Original languageEnglish (US)
Pages (from-to)134-146
Number of pages13
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1828
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Electrical Synapses
Gap Junctions
Plasticity
Plastics
Automatic Data Processing
Synaptic Transmission
Synapses
Neurons
Networks (circuits)
Processing

Keywords

  • Auditory
  • Connexin 36
  • Electrical coupling
  • Electrical synapse
  • Synaptic plasticity
  • Synchronization

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biophysics

Cite this

Gap junction-mediated electrical transmission : Regulatory mechanisms and plasticity. / Pereda, Alberto E.; Curti, Sebastian; Hoge, Gregory; Cachope, Roger; Flores, Carmen E.; Rash, John E.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1828, No. 1, 01.2013, p. 134-146.

Research output: Contribution to journalArticle

Pereda, Alberto E. ; Curti, Sebastian ; Hoge, Gregory ; Cachope, Roger ; Flores, Carmen E. ; Rash, John E. / Gap junction-mediated electrical transmission : Regulatory mechanisms and plasticity. In: Biochimica et Biophysica Acta - Biomembranes. 2013 ; Vol. 1828, No. 1. pp. 134-146.
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