Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation

Ting Wen A Lee, Hyokjoon Kwon, Haihong Zong, Eijiro Yamada, Manu Vatish, Jeffrey E. Pessin, Claire C. Bastie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Previous studies have demonstrated that Fyn knockout (FynKO) mice on a standard chow diet display increased glucose clearance and whole-body insulin sensitivity associated with decreased adiposity resulting from increased fatty acid use and energy expenditure. Surprisingly, however, despite a similar extent of adipose tissue (AT) mass accumulation on a high-fat diet, the FynKO mice remained fully glucose tolerant and insulin sensitive. Physiologic analyses demonstrated that the FynKO mice had a combination of skewed AT expansion into the subcutaneous compartment rather than to the visceral depot, reduced AT in flammation associated with reduced T-cell and macrophage in filtration, and increased proportion of anti-in flammatory M2 macrophages. These data demonstrate that Fyn is an important regulator of whole-body integrative metabolism that coordinates AT expansion, in flammation, and insulin sensitivity in states of nutrient excess. These data further suggest that inhibition of Fyn function may provide a novel target to prevent AT in flammation, insulin resistance, and the dyslipidemia components of the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)1537-1546
Number of pages10
JournalDiabetes
Volume62
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Intra-Abdominal Fat
Subcutaneous Fat
Adipose Tissue
Inflammation
Knockout Mice
Tissue Expansion
Insulin Resistance
Macrophages
Glucose
Adiposity
High Fat Diet
Dyslipidemias
Energy Metabolism
Fatty Acids
Insulin
Diet
T-Lymphocytes
Food

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. / Lee, Ting Wen A; Kwon, Hyokjoon; Zong, Haihong; Yamada, Eijiro; Vatish, Manu; Pessin, Jeffrey E.; Bastie, Claire C.

In: Diabetes, Vol. 62, No. 5, 05.2013, p. 1537-1546.

Research output: Contribution to journalArticle

Lee, Ting Wen A ; Kwon, Hyokjoon ; Zong, Haihong ; Yamada, Eijiro ; Vatish, Manu ; Pessin, Jeffrey E. ; Bastie, Claire C. / Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. In: Diabetes. 2013 ; Vol. 62, No. 5. pp. 1537-1546.
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AU - Bastie, Claire C.

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