Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation

Ting Wen A. Lee, Hyokjoon Kwon, Haihong Zong, Eijiro Yamada, Manu Vatish, Jeffrey E. Pessin, Claire C. Bastie

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Previous studies have demonstrated that Fyn knockout (FynKO) mice on a standard chow diet display increased glucose clearance and whole-body insulin sensitivity associated with decreased adiposity resulting from increased fatty acid use and energy expenditure. Surprisingly, however, despite a similar extent of adipose tissue (AT) mass accumulation on a high-fat diet, the FynKO mice remained fully glucose tolerant and insulin sensitive. Physiologic analyses demonstrated that the FynKO mice had a combination of skewed AT expansion into the subcutaneous compartment rather than to the visceral depot, reduced AT in flammation associated with reduced T-cell and macrophage in filtration, and increased proportion of anti-in flammatory M2 macrophages. These data demonstrate that Fyn is an important regulator of whole-body integrative metabolism that coordinates AT expansion, in flammation, and insulin sensitivity in states of nutrient excess. These data further suggest that inhibition of Fyn function may provide a novel target to prevent AT in flammation, insulin resistance, and the dyslipidemia components of the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)1537-1546
Number of pages10
JournalDiabetes
Volume62
Issue number5
DOIs
StatePublished - May 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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