Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats

Jana Velísková, Douglas S. Garant, Shu G. Xu, Solomon L. Moshe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35 348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABAB receptors regulate, in part, flurothyl-induced seizures.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalDevelopmental Brain Research
Volume79
Issue number2
DOIs
StatePublished - Jun 17 1994

Fingerprint

Substantia Nigra
Seizures
Flurothyl
Anticonvulsants
GABA Agents
4-Aminobutyrate Transaminase
Vigabatrin

Keywords

  • Development
  • Rat
  • Seizures
  • Substantia nigra
  • γ-Aminobutyric acid
  • γ-Aminobutyric acid receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats. / Velísková, Jana; Garant, Douglas S.; Xu, Shu G.; Moshe, Solomon L.

In: Developmental Brain Research, Vol. 79, No. 2, 17.06.1994, p. 297-300.

Research output: Contribution to journalArticle

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