Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats

Jana Velísková, Douglas S. Garant, Shu G. Xu, Solomon L. Moshé

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35 348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABAB receptors regulate, in part, flurothyl-induced seizures.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalDevelopmental Brain Research
Volume79
Issue number2
DOIs
StatePublished - Jun 17 1994

Keywords

  • Development
  • Rat
  • Seizures
  • Substantia nigra
  • γ-Aminobutyric acid
  • γ-Aminobutyric acid receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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