@article{35e48c9d9df24e14b9959ef6b2e785a5,
title = "Fungal extracellular vesicles: modulating host–pathogen interactions by both the fungus and the host",
abstract = "The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell–cell communication. In regards to host–pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host–pathogen interactions.",
keywords = "Candida, Cryptococcus, Extracellular vesicles, Fungus, Histoplasma, Paracoccidioides",
author = "D. Zamith-Miranda and L. Nimrichter and Rodrigues, {M. L.} and Nosanchuk, {J. D.}",
note = "Funding Information: J.D.N. is partially supported by NIH 3R37AI033142 and R21 AI124797. L.N. is partally supported by grant 408711/2016-7 from CNPq (National Counsel of Technological and Scientific Development, Brazil) and grant E_05/2015-214962 from FAPERJ (Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro, Brazil). M.L.R. is partially supported by grants 443586/2014-4 and 300699/2013-1 from CNPq and grant E-26/ 202.997/2015 from FAPERJ. M.L.R. holds the position (currently on a leave) of Associate Professor in the Microbiology Institute of the Federal University of Rio de Janeiro, Brazil. MLR acknowledges support from the Instituto Nacional de Ci?ncia e Tecnologia de Inovac??o em Doenc?as de Populac??es Negligenciadas (INCT-IDPN). Funding Information: J.D.N. is partially supported by NIH 3R37AI033142 and R21 AI124797 . L.N. is partally supported by grant 408711/2016-7 from CNPq (National Counsel of Technological and Scientific Development, Brazil) and grant E_05/2015-214962 from FAPERJ (Funda{\c c}{\~a}o Carlos Chagas Filho de Amparo {\`a} Pesquisa do Estado do Rio de Janeiro, Brazil). M.L.R. is partially supported by grants 443586/2014-4 and 300699/2013-1 from CNPq and grant E-26/ 202.997/2015 from FAPERJ . M.L.R. holds the position (currently on a leave) of Associate Professor in the Microbiology Institute of the Federal University of Rio de Janeiro, Brazil. MLR acknowledges support from the Instituto Nacional de Ci{\^e}ncia e Tecnologia de Inova{\c c}{\~a}o em Doen{\c c}as de Popula{\c c}{\~o}es Negligenciadas (INCT-IDPN). Publisher Copyright: {\textcopyright} 2018 Institut Pasteur",
year = "2018",
month = oct,
day = "1",
doi = "10.1016/j.micinf.2018.01.011",
language = "English (US)",
volume = "20",
pages = "501--504",
journal = "Microbes and Infection",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "9-10",
}