Abstract
The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell–cell communication. In regards to host–pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host–pathogen interactions.
| Original language | English (US) |
|---|---|
| Journal | Microbes and Infection |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Candida
- Cryptococcus
- Extracellular vesicles
- Fungus
- Histoplasma
- Paracoccidioides
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
Cite this
Fungal extracellular vesicles : modulating host–pathogen interactions by both the fungus and the host. / Zamith-Miranda, D.; Nimrichter, L.; Rodrigues, M. L.; Nosanchuk, Joshua D.
In: Microbes and Infection, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fungal extracellular vesicles
T2 - modulating host–pathogen interactions by both the fungus and the host
AU - Zamith-Miranda, D.
AU - Nimrichter, L.
AU - Rodrigues, M. L.
AU - Nosanchuk, Joshua D.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell–cell communication. In regards to host–pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host–pathogen interactions.
AB - The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell–cell communication. In regards to host–pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host–pathogen interactions.
KW - Candida
KW - Cryptococcus
KW - Extracellular vesicles
KW - Fungus
KW - Histoplasma
KW - Paracoccidioides
UR - http://www.scopus.com/inward/record.url?scp=85042602059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042602059&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2018.01.011
DO - 10.1016/j.micinf.2018.01.011
M3 - Article
C2 - 29471026
AN - SCOPUS:85042602059
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
ER -