Fungal extracellular vesicles

modulating host–pathogen interactions by both the fungus and the host

D. Zamith-Miranda, L. Nimrichter, M. L. Rodrigues, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The secretion of biomolecules by fungal cells occurs via the conventional export of signal peptide-coupled soluble molecules, but it also results from transport within extracellular vesicles (EV). During the last ten years since the description of this non-conventional secretion pathway, varied, interesting biological roles have been associated with EV release by fungi. The various organic molecules carried by these structures are involved in pathogenesis and immune evasion, and may be associated with cell–cell communication. In regards to host–pathogen interactions, EV roles are diverse and organism-specific, although some features seem to be conserved among the pathogenic fungal organisms studied to date. This review aims to highlight our current understanding of the biologically relevant findings regarding EV released by the pathogenic fungal organisms and describes our knowledge of the roles of EV in host–pathogen interactions.

Original languageEnglish (US)
JournalMicrobes and Infection
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Fungi
Immune Evasion
Secretory Pathway
Protein Sorting Signals
Extracellular Vesicles

Keywords

  • Candida
  • Cryptococcus
  • Extracellular vesicles
  • Fungus
  • Histoplasma
  • Paracoccidioides

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Fungal extracellular vesicles : modulating host–pathogen interactions by both the fungus and the host. / Zamith-Miranda, D.; Nimrichter, L.; Rodrigues, M. L.; Nosanchuk, Joshua D.

In: Microbes and Infection, 01.01.2018.

Research output: Contribution to journalArticle

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