Functional significance of alterations in cardiac contractile protein isoforms

Richard N. Kitsis, James Scheuer

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalClinical Cardiology
Volume19
Issue number1
DOIs
StatePublished - Jan 1996

Keywords

  • cardiac function
  • contractile proteins
  • heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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