Functional significance of alterations in cardiac contractile protein isoforms

Richard N. Kitsis, James Scheuer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalClinical Cardiology
Volume19
Issue number1
StatePublished - Jan 1996

Fingerprint

Contractile Proteins
Protein Isoforms
Cues

Keywords

  • cardiac function
  • contractile proteins
  • heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Functional significance of alterations in cardiac contractile protein isoforms. / Kitsis, Richard N.; Scheuer, James.

In: Clinical Cardiology, Vol. 19, No. 1, 01.1996, p. 9-18.

Research output: Contribution to journalArticle

@article{6ad3f451976a460d8b189b183f237396,
title = "Functional significance of alterations in cardiac contractile protein isoforms",
abstract = "Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.",
keywords = "cardiac function, contractile proteins, heart failure",
author = "Kitsis, {Richard N.} and James Scheuer",
year = "1996",
month = "1",
language = "English (US)",
volume = "19",
pages = "9--18",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Functional significance of alterations in cardiac contractile protein isoforms

AU - Kitsis, Richard N.

AU - Scheuer, James

PY - 1996/1

Y1 - 1996/1

N2 - Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

AB - Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

KW - cardiac function

KW - contractile proteins

KW - heart failure

UR - http://www.scopus.com/inward/record.url?scp=0029789798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029789798&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 9

EP - 18

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 1

ER -