Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy

Joseph Maldjian, Scott W. Atlas, Robert S. Howard, Elizabeth Greenstein, David Alsop, John A. Detre, John Listerud, Mark D'Esposito, Eugene S. Flamm

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Functional magnetic resonance (MR) imaging was performed in six patients harboring proven intracerebral arteriovenous malformations (AVMs) using a noninvasive blood oxygen level-dependent technique based on the documented discrepancy between regional increases in blood flow and oxygen utilization in response to regional brain activation. Statistical functional MR maps were generated and overlaid directly onto conventional MR images obtained at the same session. In the six patients studied, a total of 23 separate functional MR imaging activation studies were performed. Of these, two runs were discarded because of motion artifacts. All of the remaining 21 studies demonstrated activation in or near expected regions for the paradigm employed. Qualitatively reproducible regional localizations of functional activity in unexpected sites were also seen. The authors' findings indicating aberrant mapping of cortical function may be explained on the basis of the plasticity of brain function, in that the developing brain can take over function that would normally have been performed by regions of brain encompassed by the lesion. Preliminary results in this study's small number of cases also indicate that activity demonstrated within the confines of the apparent AVM nidus may help predict the development of a posttherapy deficit. The authors demonstrate that functional MR imaging can be successfully and reproducibly performed in patients with intracerebral AVMs. Notwithstanding the paucity of normative data using functional MR imaging, the authors' findings support cortical reorganization associated with these congenital lesions. Blood oxygen level-dependent MR imaging is a noninvasive method used to localize areas of eloquent cortex in patients harboring AVMs: it may prove to be of value in treatment planning.

Original languageEnglish (US)
Pages (from-to)477-483
Number of pages7
JournalJournal of Neurosurgery
Volume84
Issue number3
StatePublished - Mar 1996
Externally publishedYes

Fingerprint

Arteriovenous Malformations
Magnetic Resonance Imaging
Brain
Oxygen
Magnetic Resonance Spectroscopy
Therapeutics
Artifacts

Keywords

  • arteriovenous malformation
  • functional magnetic resonance imaging
  • magnetic resonance imaging
  • vascular malformation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy. / Maldjian, Joseph; Atlas, Scott W.; Howard, Robert S.; Greenstein, Elizabeth; Alsop, David; Detre, John A.; Listerud, John; D'Esposito, Mark; Flamm, Eugene S.

In: Journal of Neurosurgery, Vol. 84, No. 3, 03.1996, p. 477-483.

Research output: Contribution to journalArticle

Maldjian, J, Atlas, SW, Howard, RS, Greenstein, E, Alsop, D, Detre, JA, Listerud, J, D'Esposito, M & Flamm, ES 1996, 'Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy', Journal of Neurosurgery, vol. 84, no. 3, pp. 477-483.
Maldjian, Joseph ; Atlas, Scott W. ; Howard, Robert S. ; Greenstein, Elizabeth ; Alsop, David ; Detre, John A. ; Listerud, John ; D'Esposito, Mark ; Flamm, Eugene S. / Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy. In: Journal of Neurosurgery. 1996 ; Vol. 84, No. 3. pp. 477-483.
@article{99ecb278b27543248d6aa45602fceb22,
title = "Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy",
abstract = "Functional magnetic resonance (MR) imaging was performed in six patients harboring proven intracerebral arteriovenous malformations (AVMs) using a noninvasive blood oxygen level-dependent technique based on the documented discrepancy between regional increases in blood flow and oxygen utilization in response to regional brain activation. Statistical functional MR maps were generated and overlaid directly onto conventional MR images obtained at the same session. In the six patients studied, a total of 23 separate functional MR imaging activation studies were performed. Of these, two runs were discarded because of motion artifacts. All of the remaining 21 studies demonstrated activation in or near expected regions for the paradigm employed. Qualitatively reproducible regional localizations of functional activity in unexpected sites were also seen. The authors' findings indicating aberrant mapping of cortical function may be explained on the basis of the plasticity of brain function, in that the developing brain can take over function that would normally have been performed by regions of brain encompassed by the lesion. Preliminary results in this study's small number of cases also indicate that activity demonstrated within the confines of the apparent AVM nidus may help predict the development of a posttherapy deficit. The authors demonstrate that functional MR imaging can be successfully and reproducibly performed in patients with intracerebral AVMs. Notwithstanding the paucity of normative data using functional MR imaging, the authors' findings support cortical reorganization associated with these congenital lesions. Blood oxygen level-dependent MR imaging is a noninvasive method used to localize areas of eloquent cortex in patients harboring AVMs: it may prove to be of value in treatment planning.",
keywords = "arteriovenous malformation, functional magnetic resonance imaging, magnetic resonance imaging, vascular malformation",
author = "Joseph Maldjian and Atlas, {Scott W.} and Howard, {Robert S.} and Elizabeth Greenstein and David Alsop and Detre, {John A.} and John Listerud and Mark D'Esposito and Flamm, {Eugene S.}",
year = "1996",
month = "3",
language = "English (US)",
volume = "84",
pages = "477--483",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "3",

}

TY - JOUR

T1 - Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy

AU - Maldjian, Joseph

AU - Atlas, Scott W.

AU - Howard, Robert S.

AU - Greenstein, Elizabeth

AU - Alsop, David

AU - Detre, John A.

AU - Listerud, John

AU - D'Esposito, Mark

AU - Flamm, Eugene S.

PY - 1996/3

Y1 - 1996/3

N2 - Functional magnetic resonance (MR) imaging was performed in six patients harboring proven intracerebral arteriovenous malformations (AVMs) using a noninvasive blood oxygen level-dependent technique based on the documented discrepancy between regional increases in blood flow and oxygen utilization in response to regional brain activation. Statistical functional MR maps were generated and overlaid directly onto conventional MR images obtained at the same session. In the six patients studied, a total of 23 separate functional MR imaging activation studies were performed. Of these, two runs were discarded because of motion artifacts. All of the remaining 21 studies demonstrated activation in or near expected regions for the paradigm employed. Qualitatively reproducible regional localizations of functional activity in unexpected sites were also seen. The authors' findings indicating aberrant mapping of cortical function may be explained on the basis of the plasticity of brain function, in that the developing brain can take over function that would normally have been performed by regions of brain encompassed by the lesion. Preliminary results in this study's small number of cases also indicate that activity demonstrated within the confines of the apparent AVM nidus may help predict the development of a posttherapy deficit. The authors demonstrate that functional MR imaging can be successfully and reproducibly performed in patients with intracerebral AVMs. Notwithstanding the paucity of normative data using functional MR imaging, the authors' findings support cortical reorganization associated with these congenital lesions. Blood oxygen level-dependent MR imaging is a noninvasive method used to localize areas of eloquent cortex in patients harboring AVMs: it may prove to be of value in treatment planning.

AB - Functional magnetic resonance (MR) imaging was performed in six patients harboring proven intracerebral arteriovenous malformations (AVMs) using a noninvasive blood oxygen level-dependent technique based on the documented discrepancy between regional increases in blood flow and oxygen utilization in response to regional brain activation. Statistical functional MR maps were generated and overlaid directly onto conventional MR images obtained at the same session. In the six patients studied, a total of 23 separate functional MR imaging activation studies were performed. Of these, two runs were discarded because of motion artifacts. All of the remaining 21 studies demonstrated activation in or near expected regions for the paradigm employed. Qualitatively reproducible regional localizations of functional activity in unexpected sites were also seen. The authors' findings indicating aberrant mapping of cortical function may be explained on the basis of the plasticity of brain function, in that the developing brain can take over function that would normally have been performed by regions of brain encompassed by the lesion. Preliminary results in this study's small number of cases also indicate that activity demonstrated within the confines of the apparent AVM nidus may help predict the development of a posttherapy deficit. The authors demonstrate that functional MR imaging can be successfully and reproducibly performed in patients with intracerebral AVMs. Notwithstanding the paucity of normative data using functional MR imaging, the authors' findings support cortical reorganization associated with these congenital lesions. Blood oxygen level-dependent MR imaging is a noninvasive method used to localize areas of eloquent cortex in patients harboring AVMs: it may prove to be of value in treatment planning.

KW - arteriovenous malformation

KW - functional magnetic resonance imaging

KW - magnetic resonance imaging

KW - vascular malformation

UR - http://www.scopus.com/inward/record.url?scp=0030053306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030053306&partnerID=8YFLogxK

M3 - Article

C2 - 8609561

AN - SCOPUS:0030053306

VL - 84

SP - 477

EP - 483

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 3

ER -