Functional architecture of the mammalian striatum: Mouse vascular and striosome organization and their anatomic relationships

O. Breuer, C. Lawhorn, T. Miller, D. M. Smith, L. L. Brown

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

To determine whether the general architecture of striatal vessels and mu opioid receptor-rich striosomes is similar, we investigated 3D reconstructions of coronal sections in 10 FVB mice. The sections were stained for striosomes using a mu opioid receptor antibody (MOR1). We used computerized procedures to detect striosomes and vessels and to calculate volume, number and colocalization of striosomes and vessels. The results showed a lattice-like pattern of striosomes similar to, and often surrounding, blood vessels. Furthermore, co-localization calculations suggested that the striosomes are more vascular than the matrix. Vessel volume was 5.0 ± 1.3% per μm3 in striosomes versus 3.6 ± 0.9% μm3 in matrix (p = 0.01). The findings emphasize the probable importance of a grid- or lattice-like structure as an organizing principle of striatal anatomy and function. In addition, the greater vascularity of the striosomes compared to the matrix suggests a unique function of this compartment in relation to humoral signals and neurotropic drugs.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalNeuroscience Letters
Volume385
Issue number3
DOIs
StatePublished - Sep 16 2005

Keywords

  • Arterioles
  • Basal ganglia
  • Caudate-putamen
  • Cerebral vessels
  • Neurovascular

ASJC Scopus subject areas

  • Neuroscience(all)

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