Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma

Anna Migliazza, Stefano Martinotti, Weiyi Chen, Carlo Fusco, B. Hilda Ye, Daniel M. Knowles, Kenneth Offit, R. S K Chaganti, Riccardo Dalla-Favera

Research output: Contribution to journalArticle

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Abstract

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10-3-1.6 × 10-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.

Original languageEnglish (US)
Pages (from-to)12520-12524
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number26
StatePublished - Dec 19 1995
Externally publishedYes

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Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Immunoglobulin Genes
Mutation
Follicular Lymphoma
Zinc Fingers
Genes
Cluster Analysis
B-Lymphocytes
Transcription Factors
Alleles
Neoplasms

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. / Migliazza, Anna; Martinotti, Stefano; Chen, Weiyi; Fusco, Carlo; Ye, B. Hilda; Knowles, Daniel M.; Offit, Kenneth; Chaganti, R. S K; Dalla-Favera, Riccardo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 26, 19.12.1995, p. 12520-12524.

Research output: Contribution to journalArticle

Migliazza, A, Martinotti, S, Chen, W, Fusco, C, Ye, BH, Knowles, DM, Offit, K, Chaganti, RSK & Dalla-Favera, R 1995, 'Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 26, pp. 12520-12524.
Migliazza, Anna ; Martinotti, Stefano ; Chen, Weiyi ; Fusco, Carlo ; Ye, B. Hilda ; Knowles, Daniel M. ; Offit, Kenneth ; Chaganti, R. S K ; Dalla-Favera, Riccardo. / Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. In: Proceedings of the National Academy of Sciences of the United States of America. 1995 ; Vol. 92, No. 26. pp. 12520-12524.
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AU - Ye, B. Hilda

AU - Knowles, Daniel M.

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