Free radical production in peripheral vascular disease. A risk for critical ischaemia?

G. Ciuffetti, M. Mercuri, E. Mannarino, C. Ott, R. Lombardini, L. Pasqualini, G. Lupattelli, Laura Santambrogio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Malondialdehyde (MDA) plasma concentrations (marker of lipid free radical peroxidation) and the unfractionated leucocyte and erythrocyte filterability rates (through 5 micron Nuclepore filters in a positive pressure filtration system) were determined during a partial ischaemia induced by two consecutive treadmill tests in 64 stage II peripheral vascular disease (PVD) patients and in 32 matched controls. Transcutaneous oxygen pressure (tcPO2) was monitored constantly throughout the walking tests and recovery periods. In the PVD patients impairments in the flow properties of leucocytes and erythrocytes were associated with increases in MDA plasma concentrations which correlated significantly with a lengthening of the tcPO2 half recovery times - index of the worsening of ischaemia. Patients could be divided into two sub-groups on the basis of these impairments and their half recovery times, suggesting this experimental model may provide a means to identify those stage II PVD patients most likely to develop critical limb ischaemia.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalInternational Angiology
Volume10
Issue number2
StatePublished - 1991
Externally publishedYes

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Peripheral Vascular Diseases
Free Radicals
Ischemia
Malondialdehyde
Leukocytes
Erythrocyte Deformability
Pressure
Exercise Test
Walking
Theoretical Models
Extremities
Erythrocytes
Oxygen
Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ciuffetti, G., Mercuri, M., Mannarino, E., Ott, C., Lombardini, R., Pasqualini, L., ... Santambrogio, L. (1991). Free radical production in peripheral vascular disease. A risk for critical ischaemia? International Angiology, 10(2), 81-87.

Free radical production in peripheral vascular disease. A risk for critical ischaemia? / Ciuffetti, G.; Mercuri, M.; Mannarino, E.; Ott, C.; Lombardini, R.; Pasqualini, L.; Lupattelli, G.; Santambrogio, Laura.

In: International Angiology, Vol. 10, No. 2, 1991, p. 81-87.

Research output: Contribution to journalArticle

Ciuffetti, G, Mercuri, M, Mannarino, E, Ott, C, Lombardini, R, Pasqualini, L, Lupattelli, G & Santambrogio, L 1991, 'Free radical production in peripheral vascular disease. A risk for critical ischaemia?', International Angiology, vol. 10, no. 2, pp. 81-87.
Ciuffetti G, Mercuri M, Mannarino E, Ott C, Lombardini R, Pasqualini L et al. Free radical production in peripheral vascular disease. A risk for critical ischaemia? International Angiology. 1991;10(2):81-87.
Ciuffetti, G. ; Mercuri, M. ; Mannarino, E. ; Ott, C. ; Lombardini, R. ; Pasqualini, L. ; Lupattelli, G. ; Santambrogio, Laura. / Free radical production in peripheral vascular disease. A risk for critical ischaemia?. In: International Angiology. 1991 ; Vol. 10, No. 2. pp. 81-87.
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