Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation

Streamson C. Chua, Jr., Andrew W. Brown, Jeehee Kim, Karen L. Hennessey, Rudolph L. Leibel, Jules Hirsch

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

We have used a novel method to identify genes expressed in the hypothalamus which may be potentially involved in controlling food intake and energy metabolism. We assumed that food deprivation, a powerful stimulus of food intake, would stimulate the activity of neural pathways involved in feeding behavior which should be reflected in an increase in the synthesis of any relevant neuropeptide and its messenger RNA. A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism. In addition, we have studied the effect of the diabetes mutation on neuropeptide gene expression during fasting and refeeding. Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalMolecular Brain Research
Volume11
Issue number3-4
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Food Deprivation
Neuropeptide Y
Neuropeptides
Hypothalamus
Feeding Behavior
Gene Expression
Energy Metabolism
Mutation
Eating
Neural Pathways
Enkephalins
Nutritional Status
Fasting
Neurons
Messenger RNA
Genes

Keywords

  • Diabetes
  • Food deprivation
  • Hypothalamus
  • inbred mouse
  • Neuropeptide gene expression

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Food deprivation and hypothalamic neuropeptide gene expression : effects of strain background and the diabetes mutation. / Chua, Jr., Streamson C.; Brown, Andrew W.; Kim, Jeehee; Hennessey, Karen L.; Leibel, Rudolph L.; Hirsch, Jules.

In: Molecular Brain Research, Vol. 11, No. 3-4, 1991, p. 291-299.

Research output: Contribution to journalArticle

Chua, Jr., Streamson C. ; Brown, Andrew W. ; Kim, Jeehee ; Hennessey, Karen L. ; Leibel, Rudolph L. ; Hirsch, Jules. / Food deprivation and hypothalamic neuropeptide gene expression : effects of strain background and the diabetes mutation. In: Molecular Brain Research. 1991 ; Vol. 11, No. 3-4. pp. 291-299.
@article{49ea6928d6c44ce8b060dcc8b14802b1,
title = "Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation",
abstract = "We have used a novel method to identify genes expressed in the hypothalamus which may be potentially involved in controlling food intake and energy metabolism. We assumed that food deprivation, a powerful stimulus of food intake, would stimulate the activity of neural pathways involved in feeding behavior which should be reflected in an increase in the synthesis of any relevant neuropeptide and its messenger RNA. A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism. In addition, we have studied the effect of the diabetes mutation on neuropeptide gene expression during fasting and refeeding. Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.",
keywords = "Diabetes, Food deprivation, Hypothalamus, inbred mouse, Neuropeptide gene expression",
author = "{Chua, Jr.}, {Streamson C.} and Brown, {Andrew W.} and Jeehee Kim and Hennessey, {Karen L.} and Leibel, {Rudolph L.} and Jules Hirsch",
year = "1991",
doi = "10.1016/0169-328X(91)90038-Y",
language = "English (US)",
volume = "11",
pages = "291--299",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "3-4",

}

TY - JOUR

T1 - Food deprivation and hypothalamic neuropeptide gene expression

T2 - effects of strain background and the diabetes mutation

AU - Chua, Jr., Streamson C.

AU - Brown, Andrew W.

AU - Kim, Jeehee

AU - Hennessey, Karen L.

AU - Leibel, Rudolph L.

AU - Hirsch, Jules

PY - 1991

Y1 - 1991

N2 - We have used a novel method to identify genes expressed in the hypothalamus which may be potentially involved in controlling food intake and energy metabolism. We assumed that food deprivation, a powerful stimulus of food intake, would stimulate the activity of neural pathways involved in feeding behavior which should be reflected in an increase in the synthesis of any relevant neuropeptide and its messenger RNA. A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism. In addition, we have studied the effect of the diabetes mutation on neuropeptide gene expression during fasting and refeeding. Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.

AB - We have used a novel method to identify genes expressed in the hypothalamus which may be potentially involved in controlling food intake and energy metabolism. We assumed that food deprivation, a powerful stimulus of food intake, would stimulate the activity of neural pathways involved in feeding behavior which should be reflected in an increase in the synthesis of any relevant neuropeptide and its messenger RNA. A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism. In addition, we have studied the effect of the diabetes mutation on neuropeptide gene expression during fasting and refeeding. Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.

KW - Diabetes

KW - Food deprivation

KW - Hypothalamus

KW - inbred mouse

KW - Neuropeptide gene expression

UR - http://www.scopus.com/inward/record.url?scp=0026072307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026072307&partnerID=8YFLogxK

U2 - 10.1016/0169-328X(91)90038-Y

DO - 10.1016/0169-328X(91)90038-Y

M3 - Article

C2 - 1684630

AN - SCOPUS:0026072307

VL - 11

SP - 291

EP - 299

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 3-4

ER -