Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation

Streamson C. Chua, Andrew W. Brown, Jeehee Kim, Karen L. Hennessey, Rudolph L. Leibel, Jules Hirsch

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

We have used a novel method to identify genes expressed in the hypothalamus which may be potentially involved in controlling food intake and energy metabolism. We assumed that food deprivation, a powerful stimulus of food intake, would stimulate the activity of neural pathways involved in feeding behavior which should be reflected in an increase in the synthesis of any relevant neuropeptide and its messenger RNA. A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism. In addition, we have studied the effect of the diabetes mutation on neuropeptide gene expression during fasting and refeeding. Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalMolecular Brain Research
Volume11
Issue number3-4
DOIs
StatePublished - Oct 1991
Externally publishedYes

Keywords

  • Diabetes
  • Food deprivation
  • Hypothalamus
  • Neuropeptide gene expression
  • inbred mouse

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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