Folic acid deficiency in the United States

Folate assays in a prenatal clinic

Victor Herbert, Neville Colman, Morton Spivack, Edgar Ocasio, Vijaya Ghanta, Kenneth Kimmel, Lois Brenner, Joanne Freundlich, John Scott

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Tissue deficiency of folic acid, as measured by a red cell folate level below 150 ng. per milliliter, was present in 16 per cent of 110 sequential pregnant women at the time of their first prenatal visit to a municipal clinic. A further 14 per cent of subjects had red cell folate levels in the range "suggestive but not conclusive for tissue folate depletion" (150 to 199 ng. per milliliter). All of the subjects were from low-income families in New York City and most were black or of Puerto Rican origin. Serum folate levels showed good general correlation with red cell folate but were of less value as a diagnostic test, since they were below the lower limit of normal in 64 per cent of subjects, including many subjects who did not yet have low tissue folate. In contrast to their value in other folate deficiency states, neutrophil lobe counts showed no correlation with serum or red cell folate levels in pregnancy and thus appeared of little diagnostic value in pregnancy. It is suggested that surveys of folate deficiency in other pregnant population groups in the United States be carried out. These results support the recommendations of the Committee on Maternal Nutrition1 and the Committee on Dietary Allowances of the Food and Nutrition Board, National Research Council (U. S. A.)2 that folic acid supplements (200 to 400 μg per day) should be taken throughout pregnancy.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume123
Issue number2
StatePublished - Sep 15 1975
Externally publishedYes

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Folic Acid Deficiency
Folic Acid
Pregnancy
Serum
Population Groups
Hispanic Americans
Routine Diagnostic Tests
Pregnant Women
Neutrophils
Mothers

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Herbert, V., Colman, N., Spivack, M., Ocasio, E., Ghanta, V., Kimmel, K., ... Scott, J. (1975). Folic acid deficiency in the United States: Folate assays in a prenatal clinic. American Journal of Obstetrics and Gynecology, 123(2), 175-179.

Folic acid deficiency in the United States : Folate assays in a prenatal clinic. / Herbert, Victor; Colman, Neville; Spivack, Morton; Ocasio, Edgar; Ghanta, Vijaya; Kimmel, Kenneth; Brenner, Lois; Freundlich, Joanne; Scott, John.

In: American Journal of Obstetrics and Gynecology, Vol. 123, No. 2, 15.09.1975, p. 175-179.

Research output: Contribution to journalArticle

Herbert, V, Colman, N, Spivack, M, Ocasio, E, Ghanta, V, Kimmel, K, Brenner, L, Freundlich, J & Scott, J 1975, 'Folic acid deficiency in the United States: Folate assays in a prenatal clinic', American Journal of Obstetrics and Gynecology, vol. 123, no. 2, pp. 175-179.
Herbert V, Colman N, Spivack M, Ocasio E, Ghanta V, Kimmel K et al. Folic acid deficiency in the United States: Folate assays in a prenatal clinic. American Journal of Obstetrics and Gynecology. 1975 Sep 15;123(2):175-179.
Herbert, Victor ; Colman, Neville ; Spivack, Morton ; Ocasio, Edgar ; Ghanta, Vijaya ; Kimmel, Kenneth ; Brenner, Lois ; Freundlich, Joanne ; Scott, John. / Folic acid deficiency in the United States : Folate assays in a prenatal clinic. In: American Journal of Obstetrics and Gynecology. 1975 ; Vol. 123, No. 2. pp. 175-179.
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