TY - JOUR
T1 - Fluoxetine treatment of anger attacks
T2 - A replication study
AU - Fava, Maurizio
AU - Alpert, Jonathan
AU - Nierenberg, Andrew A.
AU - Ghaemi, Nassir
AU - O'Sullivan, Richard
AU - Tedlow, Joyce
AU - Worthington, John
AU - Rosenbaum, Jerrold F.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/3
Y1 - 1996/3
N2 - 'Anger attacks' are outbursts of anger which are accompanied by intense autonomic arousal and are clearly inappropriate to the situation in which they occur. The Anger Attacks Questionnaire, designed to assess these attacks, was administered to 164 consecutive patients (78 men and 86 women; mean age, 40.5 ± 11.0 years) diagnosed as having major depression with the Structured Clinical Interview for DSM-III-R. These patients were treated openly with fluoxetine, 20 mg/day for 8 weeks, and the prevalence of anger attacks was assessed before and after treatment. At baseline, 64 (39%) (26 men and 38 women) of these patients reported having anger attacks according to our criteria. Forty-one (64%) of the 64 depressed patients with anger attacks at baseline did not report anger attacks following fluoxetine treatment, while 7 (7%) of the 100 patients who did not have anger attacks at baseline reported these attacks following treatment, with this difference being statistically significant (χ2 = 22.7, p < .0005).
AB - 'Anger attacks' are outbursts of anger which are accompanied by intense autonomic arousal and are clearly inappropriate to the situation in which they occur. The Anger Attacks Questionnaire, designed to assess these attacks, was administered to 164 consecutive patients (78 men and 86 women; mean age, 40.5 ± 11.0 years) diagnosed as having major depression with the Structured Clinical Interview for DSM-III-R. These patients were treated openly with fluoxetine, 20 mg/day for 8 weeks, and the prevalence of anger attacks was assessed before and after treatment. At baseline, 64 (39%) (26 men and 38 women) of these patients reported having anger attacks according to our criteria. Forty-one (64%) of the 64 depressed patients with anger attacks at baseline did not report anger attacks following fluoxetine treatment, while 7 (7%) of the 100 patients who did not have anger attacks at baseline reported these attacks following treatment, with this difference being statistically significant (χ2 = 22.7, p < .0005).
KW - Anger attacks
KW - Antidepressant treatment
KW - Depression
KW - Fluoxetine
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UR - http://www.scopus.com/inward/citedby.url?scp=0029942016&partnerID=8YFLogxK
U2 - 10.3109/10401239609149084
DO - 10.3109/10401239609149084
M3 - Article
C2 - 8743642
AN - SCOPUS:0029942016
SN - 1040-1237
VL - 8
SP - 7
EP - 10
JO - Annals of Clinical Psychiatry
JF - Annals of Clinical Psychiatry
IS - 1
ER -
