FLT3-ITD gets by with a little help from PRMT1

Research output: Contribution to journalReview articlepeer-review


In this issue of Blood, He et al discuss their discovery that methylation of fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) at arginines 972 and 973 by protein arginine N-methyltransferase 1 (PRMT1) potentiates oncogenic signaling and that inhibition of PRMT1 can improve the efficacy of kinase inhibitors in FLT3-ITD acute myeloid leukemia (AML)

Original languageEnglish (US)
Pages (from-to)498-500
Number of pages3
Issue number6
StatePublished - Aug 8 2019

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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