Abstract
In this issue of Blood, He et al discuss their discovery that methylation of fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) at arginines 972 and 973 by protein arginine N-methyltransferase 1 (PRMT1) potentiates oncogenic signaling and that inhibition of PRMT1 can improve the efficacy of kinase inhibitors in FLT3-ITD acute myeloid leukemia (AML)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 498-500 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 134 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 8 2019 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology