FLT3-ITD gets by with a little help from PRMT1

Kira Gritsman

Research output: Contribution to journal › Review article

Abstract

In this issue of Blood, He et al discuss their discovery that methylation of fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) at arginines 972 and 973 by protein arginine N-methyltransferase 1 (PRMT1) potentiates oncogenic signaling and that inhibition of PRMT1 can improve the efficacy of kinase inhibitors in FLT3-ITD acute myeloid leukemia (AML)

Original languageEnglish (US)
Pages (from-to)498-500
Number of pages3
JournalBlood
Volume134
Issue number6
DOIs
StatePublished - Aug 8 2019

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fms-Like Tyrosine Kinase 3
Protein-Arginine N-Methyltransferases
Methylation
Acute Myeloid Leukemia
Arginine
Blood
Phosphotransferases

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

FLT3-ITD gets by with a little help from PRMT1. / Gritsman, Kira.

In: Blood, Vol. 134, No. 6, 08.08.2019, p. 498-500.

Research output: Contribution to journal › Review article

Gritsman, K 2019, 'FLT3-ITD gets by with a little help from PRMT1', Blood, vol. 134, no. 6, pp. 498-500. https://doi.org/10.1182/blood.2019001876
Gritsman K. FLT3-ITD gets by with a little help from PRMT1. Blood. 2019 Aug 8;134(6):498-500. https://doi.org/10.1182/blood.2019001876
Gritsman, Kira. / FLT3-ITD gets by with a little help from PRMT1. In: Blood. 2019 ; Vol. 134, No. 6. pp. 498-500.
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