First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART): A FASTER trial study

G. Lambert-Messerlian, L. Dugoff, J. Vidaver, J. A. Canick, F. D. Malone, R. H. Ball, C. H. Comstock, D. A. Nyberg, G. Saade, K. Eddleman, S. Klugman, S. D. Craigo, I. E. Timor-Tritsch, S. R. Carr, H. M. Wolfe, M. E. D'Alton

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Objective: To determine whether first- and second-trimester Down syndrome screening markers and screen-positive rates are altered in pregnancies conceived using assisted reproductive technologies (ARTs). Methods: ART pregnancies in the multicenter FASTER trial were identified. Marker levels were evaluated for five types of ART: in vitro fertilization with ovulation induction (IVF-OI), IVF with OI and egg donation (IVF-OI-ED), IVF with ED (IVF-ED), and intrauterine insemination with OI (IUI-OI) or without OI (IUI). Each group was compared to non-ART controls using Mann-Whitney U analysis. Results: First-trimester marker levels were not significantly different between ART and control pregnancies, with the exception of reduced PAPP-A levels in the IUI-OI group. In contrast, second-trimester inhibin A levels were increased in all ART pregnancies, estriol was reduced and human chorionic gonadotropin (hCG) was increased in IVF and IUI pregnancies without ED, and alpha-fetoprotein (AFP) was increased in ED pregnancies. Second-trimester screen-positive rates were significantly higher than expected for ART pregnancies, except when ED was used. Conclusions: These data show that ART significantly impacts second-, but not first-, trimester markers and screen-positive rates. The type of adjustment needed in second-trimester screening depends on the particular type of ART used.

Original languageEnglish (US)
Pages (from-to)672-678
Number of pages7
JournalPrenatal Diagnosis
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2006

Keywords

  • Assisted reproduction
  • Down syndrome
  • Maternal serum screening
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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    Lambert-Messerlian, G., Dugoff, L., Vidaver, J., Canick, J. A., Malone, F. D., Ball, R. H., Comstock, C. H., Nyberg, D. A., Saade, G., Eddleman, K., Klugman, S., Craigo, S. D., Timor-Tritsch, I. E., Carr, S. R., Wolfe, H. M., & D'Alton, M. E. (2006). First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART): A FASTER trial study. Prenatal Diagnosis, 26(8), 672-678. https://doi.org/10.1002/pd.1469