Fibroblasts in the Infarcted, Remodeling, and Failing Heart

Claudio Humeres, Nikolaos G. Frangogiannis

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.

Original languageEnglish (US)
Pages (from-to)449-467
Number of pages19
JournalJACC: Basic to Translational Science
Volume4
Issue number3
DOIs
StatePublished - Jun 1 2019

Fingerprint

Fibroblasts
Extracellular Matrix
Fibrosis
Extracellular Matrix Proteins
Cardiac Myocytes
Myocardium
Inflammation
Wounds and Injuries

Keywords

  • cytokines
  • extracellular matrix
  • fibroblast
  • infarction
  • remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Fibroblasts in the Infarcted, Remodeling, and Failing Heart. / Humeres, Claudio; Frangogiannis, Nikolaos G.

In: JACC: Basic to Translational Science, Vol. 4, No. 3, 01.06.2019, p. 449-467.

Research output: Contribution to journalReview article

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