Abstract
Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 449-467 |
| Number of pages | 19 |
| Journal | JACC: Basic to Translational Science |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2019 |
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Keywords
- cytokines
- extracellular matrix
- fibroblast
- infarction
- remodeling
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Fibroblasts in the Infarcted, Remodeling, and Failing Heart. / Humeres, Claudio; Frangogiannis, Nikolaos G.
In: JACC: Basic to Translational Science, Vol. 4, No. 3, 01.06.2019, p. 449-467.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Fibroblasts in the Infarcted, Remodeling, and Failing Heart
AU - Humeres, Claudio
AU - Frangogiannis, Nikolaos G.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
AB - Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
KW - cytokines
KW - extracellular matrix
KW - fibroblast
KW - infarction
KW - remodeling
UR - http://www.scopus.com/inward/record.url?scp=85067245034&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067245034&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2019.02.006
DO - 10.1016/j.jacbts.2019.02.006
M3 - Review article
AN - SCOPUS:85067245034
VL - 4
SP - 449
EP - 467
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 3
ER -