Fibroblasts in the Infarcted, Remodeling, and Failing Heart

Claudio Humeres, Nikolaos G. Frangogiannis

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations


Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.

Original languageEnglish (US)
Pages (from-to)449-467
Number of pages19
JournalJACC: Basic to Translational Science
Issue number3
StatePublished - Jun 2019


  • cytokines
  • extracellular matrix
  • fibroblast
  • infarction
  • remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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