TY - JOUR
T1 - Fibroblasts in the Infarcted, Remodeling, and Failing Heart
AU - Humeres, Claudio
AU - Frangogiannis, Nikolaos G.
N1 - Funding Information:
Dr. Frangogiannis’s laboratory is supported by National Institutes of Health grants R01 HL76246 and R01 HL85440 and by U.S. Department of Defense grants PR151134 and PR151029. Dr. Humeres is supported by American Heart Association post-doctoral award 19POST34450144. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2019 The Authors
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
AB - Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
KW - cytokines
KW - extracellular matrix
KW - fibroblast
KW - infarction
KW - remodeling
UR - http://www.scopus.com/inward/record.url?scp=85067245034&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067245034&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2019.02.006
DO - 10.1016/j.jacbts.2019.02.006
M3 - Review article
AN - SCOPUS:85067245034
VL - 4
SP - 449
EP - 467
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 3
ER -