Fibroblast-like synoviocytes in inflammatory arthritis pathology: The emerging role of cadherin-11

Sook Kyung Chang, Zhizhan Gu, Michael B. Brenner

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting the joint synovium. The normal synovium consists of a lining layer of fibroblast-like synoviocytes (FLS) and macrophages, one to three cells deep that overlies the loose connective tissue of the synovial sublining. During the course of RA, the synovium is the site of inflammation where immune cells are massively infiltrated, and the lining layer becomes hyperplastic and transforms into a pannus tissue that destroys articular cartilage and bone. FLS play an important role in this RA pathogenesis. In this review, we explain that cadherin-11, an adhesion molecule, is selectively expressed on FLS and required for synovial lining formation. In addition, cadherin-11 on FLS contributes to synovial inflammation and mediates cartilage degradation in a mouse model of inflammatory arthritis. Therefore, we suggest that FLS are critical regulators of synovial inflammation and arthritis pathology via mechanisms that are mediated by cadherin-11.

Original languageEnglish (US)
Pages (from-to)256-266
Number of pages11
JournalImmunological Reviews
Volume233
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Arthritis
Fibroblasts
Synovial Membrane
Pathology
Rheumatoid Arthritis
Inflammation
Articular Cartilage
Connective Tissue
Autoimmune Diseases
Cartilage
Joints
Macrophages
Synoviocytes
osteoblast cadherin
Bone and Bones

Keywords

  • Adhesion molecules
  • Fibroblast-like synoviocytes
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Fibroblast-like synoviocytes in inflammatory arthritis pathology : The emerging role of cadherin-11. / Kyung Chang, Sook; Gu, Zhizhan; Brenner, Michael B.

In: Immunological Reviews, Vol. 233, No. 1, 01.2010, p. 256-266.

Research output: Contribution to journalArticle

Kyung Chang, Sook ; Gu, Zhizhan ; Brenner, Michael B. / Fibroblast-like synoviocytes in inflammatory arthritis pathology : The emerging role of cadherin-11. In: Immunological Reviews. 2010 ; Vol. 233, No. 1. pp. 256-266.
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