Fetal hiccups in the baboon

R. I. Stark, S. S. Daniel, M. Garland, J. C. Jaille-Marti, Y. I. Kim, K. Leung, M. M. Myers, P. J. Tropper

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bouts of hiccuping are recognized by pregnant women as distinct episodic movements of their fetuses. Ultrasound imaging of these fetuses has documented the occurrence of hiccups from early gestation through parturition. This study provides a systematic characterization of prenatal hiccuping in the fetal baboon (Papio species). Tracheal fluid pressure was recorded from 11 chronically instrumented fetal baboons for 21.5 ± 7.3 consecutive days (mean ± SD) over a range in gestation from 124 to 164 days (term 175 days). In an initial review of pressure recordings by visual inspection, hiccups were recognized as distinctive high-amplitude fluctuations in tracheal pressure that were readily discriminated from fetal breaths. Automated techniques were then developed and validated to detect hiccups and summarize their features. The mean hiccup amplitude was 23.0 ± 3.1 mmHg, inspiratory time was 0.26 ± 0.03 s, and expiratory time was 0.27 ± 0.02 s. Each of these features discriminated hiccups from breaths (P < 0.001). Hiccuping incidence (1.8 ± 0.4% of time), rate (26.2 ± 6.2 min- 1), bout duration (4.3 ± 0.8 min), and the interval between bouts (3.35 ± 0.60 h) were also different (P < 0.01) from breathing. These features of hiccups remained relatively constant over the latter third of gestation with the exception of an increase in duration of the expiratory time interval (r = 0.54, P < 0.01). Despite their vigorous nature, bouts of hiccuping were not associated with transitions in behavioral state. Moreover, the features of hiccups were not differentiated by state. Bouts of hiccuping recurred in a cyclic fashion, on average every 3-4 h. The duration of bouts had a diurnal rhythmicity (r = 0.59, P < 0.005), with longer bouts at night than during the day. It is concluded that the mechanisms generating hiccups are largely distinct from those that regulate fetal breathing and that the characteristics of hiccups and bouts of hiccuping are similar across primate species.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume267
Issue number6 36-6
StatePublished - 1994
Externally publishedYes

Fingerprint

Hiccup
Papio
Pressure
Pregnancy
Respiration
Fetus
Periodicity
Primates
Pregnant Women
Ultrasonography
Parturition

Keywords

  • behavioral state
  • breathing activity
  • diurnal rhythm
  • electroencephalogram
  • fetus
  • nonhuman primate
  • singultus
  • tracheal fluid pressure

ASJC Scopus subject areas

  • Physiology

Cite this

Stark, R. I., Daniel, S. S., Garland, M., Jaille-Marti, J. C., Kim, Y. I., Leung, K., ... Tropper, P. J. (1994). Fetal hiccups in the baboon. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 267(6 36-6).

Fetal hiccups in the baboon. / Stark, R. I.; Daniel, S. S.; Garland, M.; Jaille-Marti, J. C.; Kim, Y. I.; Leung, K.; Myers, M. M.; Tropper, P. J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 267, No. 6 36-6, 1994.

Research output: Contribution to journalArticle

Stark, RI, Daniel, SS, Garland, M, Jaille-Marti, JC, Kim, YI, Leung, K, Myers, MM & Tropper, PJ 1994, 'Fetal hiccups in the baboon', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 267, no. 6 36-6.
Stark RI, Daniel SS, Garland M, Jaille-Marti JC, Kim YI, Leung K et al. Fetal hiccups in the baboon. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1994;267(6 36-6).
Stark, R. I. ; Daniel, S. S. ; Garland, M. ; Jaille-Marti, J. C. ; Kim, Y. I. ; Leung, K. ; Myers, M. M. ; Tropper, P. J. / Fetal hiccups in the baboon. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1994 ; Vol. 267, No. 6 36-6.
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