Fe(III)-catalyzed cross-coupling between functionalized arylmagnesium compounds and alkenyl halides

W. Dohle, F. Kopp, G. Cahiez, P. Knochel

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Abstract

Functionalized arylmagnesium reagents bearing an ester, cyano, nonaflate or trialkylsilyloxy group undergo fast cross-coupling reactions with alkenyl iodides or bromides in the presence of catalytic amounts of Fe(acac)3 (5 mol%) at-20 °C within 1 hour resulting in the formation of the desired cross-coupling products in satisfactory yields. Excellent yields can be achieved by performing the cross-coupling reaction on solid phase by generating the Grignard reagent on the resin.

Original languageEnglish (US)
Pages (from-to)1901-1904
Number of pages4
JournalSynlett
Issue number12
DOIs
Publication statusPublished - Jan 1 2001

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Keywords

  • Cross-coupling reaction
  • Iodine-magnesium exchange
  • Iron(III)-catalysis
  • Magnesium

ASJC Scopus subject areas

  • Organic Chemistry

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