Feeling unreal: A PET study of depersonalization disorder

D. Simeon, O. Guralnik, E. A. Hazlett, J. Spiegel-Cohen, Eric Hollander, M. S. Buchsbaum

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Objective: The goal of this study was to assess brain glucose metabolism and its relationship to dissociation measures and clinical symptoms in DSM-IV depersonalization disorder. Method: Positron emission tomography scans coregistered with magnetic resonance images of eight subjects with depersonalization disorder were compared to those of 24 healthy comparison subjects. The two groups did not differ in age, sex, education, performance on a baseline neuropsychological battery, or performance on a verbal learning task administered during [18F]fluorodeoxyglucose uptake. A cortical analysis by individual Brodmann's areas was performed. Results: Compared to the healthy subjects, subjects with depersonalization disorder showed significantly lower metabolic activity in right Brodmann's areas 22 and 21 of the superior and middle temporal gyri and had significantly higher metabolism in parietal Brodmann's areas 7B and 39 and left occipital Brodmann's area 19. Dissociation and depersonalization scores among the subjects with depersonalization disorder were significantly positively correlated with metabolic activity in area 7B. Conclusions: Depersonalization appears to be associated with functional abnormalities along sequential hierarchical areas, secondary and cross-modal, of the sensory cortex (visual, auditory, and somatosensory), as well as areas responsible for an integrated body schema. These findings are in good agreement with the phenomenological conceptualization of depersonalization as a dissociation of perceptions as well as with the subjective symptoms of depersonalization disorder.

Original languageEnglish (US)
Pages (from-to)1782-1788
Number of pages7
JournalAmerican Journal of Psychiatry
Volume157
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Depersonalization
Emotions
Dissociative Disorders
Healthy Volunteers
Verbal Learning
Auditory Cortex
Somatosensory Cortex
Sex Education
Body Image
Fluorodeoxyglucose F18
Visual Cortex
Temporal Lobe
Diagnostic and Statistical Manual of Mental Disorders
Positron-Emission Tomography
Magnetic Resonance Spectroscopy
Glucose
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Simeon, D., Guralnik, O., Hazlett, E. A., Spiegel-Cohen, J., Hollander, E., & Buchsbaum, M. S. (2000). Feeling unreal: A PET study of depersonalization disorder. American Journal of Psychiatry, 157(11), 1782-1788. https://doi.org/10.1176/appi.ajp.157.11.1782

Feeling unreal : A PET study of depersonalization disorder. / Simeon, D.; Guralnik, O.; Hazlett, E. A.; Spiegel-Cohen, J.; Hollander, Eric; Buchsbaum, M. S.

In: American Journal of Psychiatry, Vol. 157, No. 11, 2000, p. 1782-1788.

Research output: Contribution to journalArticle

Simeon, D, Guralnik, O, Hazlett, EA, Spiegel-Cohen, J, Hollander, E & Buchsbaum, MS 2000, 'Feeling unreal: A PET study of depersonalization disorder', American Journal of Psychiatry, vol. 157, no. 11, pp. 1782-1788. https://doi.org/10.1176/appi.ajp.157.11.1782
Simeon, D. ; Guralnik, O. ; Hazlett, E. A. ; Spiegel-Cohen, J. ; Hollander, Eric ; Buchsbaum, M. S. / Feeling unreal : A PET study of depersonalization disorder. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 11. pp. 1782-1788.
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