FAT10: A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy

Alexandra Snyder, Zygimantas Alsauskas, Pengfei Gong, Paul E. Rosenstiel, Mary E. Klotman, Paul E. Klotman, Michael J. Ross

Research output: Contribution to journalArticle

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Abstract

Human immunodeficiency virus (HIV)-associated nephropathy is a significant cause of morbidity and mortality in HIV-infected persons. Vpr-induced cell cycle dysregulation and apoptosis of renal tubular epithelial cells are important components of the pathogenesis of HIV-associated nephropathy (HIVAN). FAT10 is a ubiquitin-like protein that is upregulated in renal tubular epithelial cells in HIVAN. In these studies, we report that Vpr induces increased expression of FAT10 in tubular cells and that inhibition of FAT10 expression prevents Vpr-induced apoptosis in human and murine tubular cells. Moreover, we found that Vpr interacts with FAT10 and that these proteins colocalize at mitochondria. These studies establish FAT10 as a novel mediator of Vpr-induced cell death.

Original languageEnglish (US)
Pages (from-to)11983-11988
Number of pages6
JournalJournal of Virology
Volume83
Issue number22
DOIs
StatePublished - Nov 2009
Externally publishedYes

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AIDS-Associated Nephropathy
Human immunodeficiency virus
kidney diseases
apoptosis
kidney cells
Apoptosis
epithelial cells
Epithelial Cells
Ubiquitins
Kidney
Cellular Structures
ubiquitin
morbidity
cell death
cell cycle
Cell Cycle
Mitochondria
mitochondria
Cell Death
pathogenesis

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Snyder, A., Alsauskas, Z., Gong, P., Rosenstiel, P. E., Klotman, M. E., Klotman, P. E., & Ross, M. J. (2009). FAT10: A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. Journal of Virology, 83(22), 11983-11988. https://doi.org/10.1128/JVI.00034-09

FAT10 : A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. / Snyder, Alexandra; Alsauskas, Zygimantas; Gong, Pengfei; Rosenstiel, Paul E.; Klotman, Mary E.; Klotman, Paul E.; Ross, Michael J.

In: Journal of Virology, Vol. 83, No. 22, 11.2009, p. 11983-11988.

Research output: Contribution to journalArticle

Snyder, A, Alsauskas, Z, Gong, P, Rosenstiel, PE, Klotman, ME, Klotman, PE & Ross, MJ 2009, 'FAT10: A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy', Journal of Virology, vol. 83, no. 22, pp. 11983-11988. https://doi.org/10.1128/JVI.00034-09
Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE et al. FAT10: A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. Journal of Virology. 2009 Nov;83(22):11983-11988. https://doi.org/10.1128/JVI.00034-09
Snyder, Alexandra ; Alsauskas, Zygimantas ; Gong, Pengfei ; Rosenstiel, Paul E. ; Klotman, Mary E. ; Klotman, Paul E. ; Ross, Michael J. / FAT10 : A novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. In: Journal of Virology. 2009 ; Vol. 83, No. 22. pp. 11983-11988.
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