Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children

Steven Shea, Eve Aymong, Patricia Zybert, Lars Berglund, Harry Shamoon, Richard J. Deckelbaum, Charles E. Basch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Obesity and hyperinsulinemia are associated with dyslipidemia in adults and older children, but little is known about these relationships in very young children. We examined the relation of fasting insulin to lipid levels and lipid particle size in young healthy children. Research Methods and Procedures: Analyses were performed on data from 491 healthy 2- and 3-year old Hispanic children enrolled in a dietary study conducted in New York City, 1992-1995. Obesity measures included BMI, ponderal index, skinfold thickness, and waist circumference. Low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol particle size were measured by nuclear magnetic resonance. Results: Fasting insulin level was positively correlated with triglyceride levels (r = 0.24 for boys and r = 0.23 for girls; p < 0.001 for both) and inversely correlated with HDL-cholesterol level in boys (r = -0.20; p < 0.01). Higher fasting insulin level was also correlated with smaller mean HDL particle size in both boys (r = -0.21; p < 0.001) and girls (r = -0.14; p < 0.05) and smaller mean LDL particle size in boys (r = -0.13; p < 0.05). The associations of fasting insulin level with triglyceride and HDL-cholesterol levels and HDL and LDL particle size remained significant after multivariate regression adjustment for age, sex, and BMI or ponderal index. Discussion: Fasting insulin level is associated with relative dyslipidemia in healthy 2- and 3-year-old Hispanic children.

Original languageEnglish (US)
Pages (from-to)709-721
Number of pages13
JournalObesity Research
Volume11
Issue number6
StatePublished - 2003

Fingerprint

Particle Size
fasting
particle size
Fasting
insulin
Insulin
Lipids
low density lipoprotein
LDL Lipoproteins
high density lipoprotein cholesterol
HDL Cholesterol
lipids
high density lipoprotein
hyperlipidemia
HDL Lipoproteins
Dyslipidemias
Hispanic Americans
Triglycerides
obesity
Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Shea, S., Aymong, E., Zybert, P., Berglund, L., Shamoon, H., Deckelbaum, R. J., & Basch, C. E. (2003). Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. Obesity Research, 11(6), 709-721.

Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. / Shea, Steven; Aymong, Eve; Zybert, Patricia; Berglund, Lars; Shamoon, Harry; Deckelbaum, Richard J.; Basch, Charles E.

In: Obesity Research, Vol. 11, No. 6, 2003, p. 709-721.

Research output: Contribution to journalArticle

Shea, S, Aymong, E, Zybert, P, Berglund, L, Shamoon, H, Deckelbaum, RJ & Basch, CE 2003, 'Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children', Obesity Research, vol. 11, no. 6, pp. 709-721.
Shea S, Aymong E, Zybert P, Berglund L, Shamoon H, Deckelbaum RJ et al. Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. Obesity Research. 2003;11(6):709-721.
Shea, Steven ; Aymong, Eve ; Zybert, Patricia ; Berglund, Lars ; Shamoon, Harry ; Deckelbaum, Richard J. ; Basch, Charles E. / Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. In: Obesity Research. 2003 ; Vol. 11, No. 6. pp. 709-721.
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