False-negative cerebrospinal fluid cryptococcal latex agglutination tests for patients with culture-positive cryptococcal meningitis

B. P. Currie, L. F. Freundlich, M. A. Soto, A. Casadevall

Research output: Contribution to journalComment/debate

58 Scopus citations

Abstract

Three cases of false-negative cerebrospinal fluid latex agglutination test results for patients with culture-positive cryptococcal meningitis are reported. False-negative results occurred in settings of low cryptococcal antigen concentrations in cerebrospinal fluid and were dependent on the latex agglutination test kit used. Investigation of each case revealed that prozone phenomena or interference from bound antibody or protein could not account for the false-negative results.

Original languageEnglish (US)
Pages (from-to)2519-2522
Number of pages4
JournalJournal of Clinical Microbiology
Volume31
Issue number9
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)

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