Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women

Eva A. Operskalski, Wendy J. Mack, Howard Strickler, Audrey L. French, Michael Augenbraun, Phyllis C. Tien, Maria C. Villacres, LaShonda Y. Spencer, Marina DeGiacomo, Andrea Kovacs

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Co-infection with hepatitis C virus (HCV) is common among HIV-infected women. Objective: To further our understanding of the risk factors for HCV viremia and the predictors of HCV viral load among women. Study design: We investigated sociodemographic, immunologic, and virologic factors associated with presence and level of HCV viremia among 1049 HCV-seropositive women, 882 of whom were HIV-infected and 167 HIV-uninfected at their entry into the Women's Interagency HIV Study. Results: Plasma HCV RNA was detected in 852 (81%) of these 1049 women (range: 1.2-7.8 log10 copies/ml). HCV-viremic women were more likely to have an HIV RNA level >100,000 copies/ml (P = 0.0004), to have reported smoking (P = 0.01), or to be Black (P = 0.005). They were less likely to have current or resolved hepatitis B infection. HCV RNA levels were higher in women who were >35 years old, or HIV-infected. Current smoking and history of drug use (crack/freebase cocaine, marijuana, amphetamines, or heroin) were each associated with both presence and level of viremia. Conclusions: Substance abuse counseling aimed at eliminating ongoing use of illicit drugs and tobacco may reduce clinical progression, improve response to treatment, and decrease HCV transmission by lowering levels of HCV viremia in women.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalJournal of Clinical Virology
Volume41
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Viremia
Hepatitis C
Hepacivirus
HIV
RNA
Smoking
Crack Cocaine
Amphetamines
Heroin
Immunologic Factors
Street Drugs
Cannabis
Viral Load
Hepatitis B
Coinfection
Substance-Related Disorders
Tobacco
Counseling

Keywords

  • Hepatitis C
  • Hepatitis C RNA levels
  • Hepatitis C viremia
  • HIV/hepatitis C virus co-infection

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women. / Operskalski, Eva A.; Mack, Wendy J.; Strickler, Howard; French, Audrey L.; Augenbraun, Michael; Tien, Phyllis C.; Villacres, Maria C.; Spencer, LaShonda Y.; DeGiacomo, Marina; Kovacs, Andrea.

In: Journal of Clinical Virology, Vol. 41, No. 4, 04.2008, p. 255-263.

Research output: Contribution to journalArticle

Operskalski, EA, Mack, WJ, Strickler, H, French, AL, Augenbraun, M, Tien, PC, Villacres, MC, Spencer, LY, DeGiacomo, M & Kovacs, A 2008, 'Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women', Journal of Clinical Virology, vol. 41, no. 4, pp. 255-263. https://doi.org/10.1016/j.jcv.2007.08.021
Operskalski, Eva A. ; Mack, Wendy J. ; Strickler, Howard ; French, Audrey L. ; Augenbraun, Michael ; Tien, Phyllis C. ; Villacres, Maria C. ; Spencer, LaShonda Y. ; DeGiacomo, Marina ; Kovacs, Andrea. / Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women. In: Journal of Clinical Virology. 2008 ; Vol. 41, No. 4. pp. 255-263.
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AU - Augenbraun, Michael

AU - Tien, Phyllis C.

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