TY - JOUR
T1 - Factors affecting growth in infants with single ventricle physiology
T2 - A report from the pediatric heart network infant single ventricle trial
AU - Williams, Richard V.
AU - Zak, Victor
AU - Ravishankar, Chitra
AU - Altmann, Karen
AU - Anderson, Jeffrey
AU - Atz, Andrew M.
AU - Dunbar-Masterson, Carolyn
AU - Ghanayem, Nancy
AU - Lambert, Linda
AU - Lurito, Karen
AU - Medoff-Cooper, Barbara
AU - Margossian, Renee
AU - Pemberton, Victoria L.
AU - Russell, Jennifer
AU - Stylianou, Mario
AU - Hsu, Daphne
N1 - Funding Information:
Supported by the National Heart, Lung, and Blood Institute (U01 grants HL068269, HL068270, HL068279, HL068281, HL068285, HL068292, HL068290, HL068288, HL085057 ) and the US Food and Drug Administration Office of Orphan Products Development . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of National Heart, Lung, and Blood Institute or National Institutes of Health. The authors declare no conflicts of interest.
PY - 2011/12
Y1 - 2011/12
N2 - Objectives: To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. Study design: Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 ± 1.8 months, period 1) and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model. Results: Weights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R2 = 0.39, P <.001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R2 = 0.10, P =.002). Conclusions: Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score.
AB - Objectives: To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. Study design: Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 ± 1.8 months, period 1) and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model. Results: Weights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R2 = 0.39, P <.001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R2 = 0.10, P =.002). Conclusions: Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score.
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U2 - 10.1016/j.jpeds.2011.05.051
DO - 10.1016/j.jpeds.2011.05.051
M3 - Article
C2 - 21784436
AN - SCOPUS:80755133428
SN - 0022-3476
VL - 159
SP - 1017-1022.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -