Factor analysis of repetitive behaviors in autism as measured by the Y-BOCS

Evdokia Anagnostou, William Chaplin, Dryden Watner, Jeremy M. Silverman, Christopher J. Smith, Karen Zagursky, Lauren A. Kryzak, Thomas E. Corwin, Nicole Feirsen, Nadia Tanel, Eric Hollander

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at the category level in order to reduce the number of variables in this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. The authors estimated a tetrachoric correlation matrix among the dichotomous symptom categories and then used exploratory and confirmatory factor analyses to identify a clinically meaningful factor structure for this correlation matrix. Their analysis supported a four-factor solution: obsessions, higher-order repetitive behaviors, lower-order repetitive behaviors, and hoarding. These findings are another step in the effort to identify genetically and biologically distinct groups within this population.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume23
Issue number3
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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