Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume45
Issue number2
DOIs
StatePublished - Feb 17 2017

Keywords

  • Curcumin
  • drug delivery
  • nanospheres
  • poly(ethylene glycol)–poly(lactic acid)

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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