Abstract
Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.
Original language | English (US) |
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Pages (from-to) | 297-304 |
Number of pages | 8 |
Journal | Artificial Cells, Nanomedicine and Biotechnology |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - Feb 17 2017 |
Keywords
- Curcumin
- drug delivery
- nanospheres
- poly(ethylene glycol)–poly(lactic acid)
ASJC Scopus subject areas
- Biotechnology
- Medicine (miscellaneous)
- Biomedical Engineering
- Pharmaceutical Science