Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

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14 Citations (Scopus)

Abstract

Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalArtificial Cells, Nanomedicine and Biotechnology
DOIs
StateAccepted/In press - Feb 24 2016

Fingerprint

Nanospheres
Curcumin
Lactic acid
Solubility
Polyethylene glycols
Stabilization
Fabrication
Fluorescence microscopy
Hydrophobicity
Emulsions
Cells
Nanoparticles
Hydrophobic and Hydrophilic Interactions
Fluorescence Microscopy
Vasodilation
Antineoplastic Agents
Biological Availability
poly(lactic acid-ethylene glycol)
Neoplasms

Keywords

  • Curcumin
  • drug delivery
  • nanospheres
  • poly(ethylene glycol)–poly(lactic acid)

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

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abstract = "Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.",
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AU - Friedman, Joel M.

AU - Nacharaju, Parimala

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AB - Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

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