Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity

Jennifer L. Dotson, Jeffrey S. Hyams, James Markowitz, Neal S. Leleiko, David R. MacK, Jonathan S. Evans, Marian D. Pfefferkorn, Anne M. Griffiths, Anthony R. Otley, Athos Bousvaros, Subra Kugathasan, Joel R. Rosh, David Keljo, Ryan S. Carvalho, Gitit Tomer, Petar Mamula, Marsha H. Kay, Benny Kerzner, Maria Oliva-Hemker, Christine R. Langton & 1 others Wallace Crandall

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Objectives: Although it is known that extraintestinal manifestations (EIMs) commonly occur in pediatric inflammatory bowel disease (IBD), little research has examined rates of EIMs and their relation to other disease-related factors in this population. The purpose of this study was to determine the rates of EIMs in pediatric IBD and examine correlations with age, sex, diagnosis, disease severity, and distribution. Patients and Methods: Data were prospectively collected as part of the Pediatric IBD Collaborative Research Group Registry, an observational database enrolling newly diagnosed IBD patients <16 years old since 2002. Rates of EIM (occurring anytime during the period of enrollment) and the aforementioned variables (at baseline) were examined. Patients with indeterminate colitis were excluded from the analysis given the relatively small number of patients. Results: One thousand nine patients were enrolled (mean age 11.6 ± 3.1 years, 57.5% boys, mean follow-up 26.2 ± 18.2 months). Two hundred eighty-five (28.2%) patients experienced 1 or more EIMs. Eighty-seven percent of EIM occurred within the first year. Increased disease severity at baseline (mild vs moderate/severe) was associated with the occurrence of any EIM (P < 0.001), arthralgia (P = 0.024), aphthous stomatitis (P = 0.001), and erythema nodosum (P = 0.009) for both Crohn disease (CD) and ulcerative colitis (UC) during the period of follow-up. Statistically significant differences in the rates of EIMs between CD and UC were seen for aphthous stomatitis, erythema nodosum, and sclerosing cholangitis. Conclusions: EIMs as defined in this study occur in approximately one quarter of pediatric patients with IBD. Disease type and disease severity were commonly associated with the occurrence of EIMs.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume51
Issue number2
DOIs
StatePublished - Aug 2010
Externally publishedYes

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Inflammatory Bowel Diseases
Pediatrics
Aphthous Stomatitis
Erythema Nodosum
Ulcerative Colitis
Crohn Disease
Sclerosing Cholangitis
Arthralgia
Colitis
Research
Registries
Databases
Population

Keywords

  • Crohn disease
  • extraintestinal manifestations
  • inflammatory bowel disease
  • pediatric
  • ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. / Dotson, Jennifer L.; Hyams, Jeffrey S.; Markowitz, James; Leleiko, Neal S.; MacK, David R.; Evans, Jonathan S.; Pfefferkorn, Marian D.; Griffiths, Anne M.; Otley, Anthony R.; Bousvaros, Athos; Kugathasan, Subra; Rosh, Joel R.; Keljo, David; Carvalho, Ryan S.; Tomer, Gitit; Mamula, Petar; Kay, Marsha H.; Kerzner, Benny; Oliva-Hemker, Maria; Langton, Christine R.; Crandall, Wallace.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 51, No. 2, 08.2010, p. 140-145.

Research output: Contribution to journalArticle

Dotson, JL, Hyams, JS, Markowitz, J, Leleiko, NS, MacK, DR, Evans, JS, Pfefferkorn, MD, Griffiths, AM, Otley, AR, Bousvaros, A, Kugathasan, S, Rosh, JR, Keljo, D, Carvalho, RS, Tomer, G, Mamula, P, Kay, MH, Kerzner, B, Oliva-Hemker, M, Langton, CR & Crandall, W 2010, 'Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity', Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 2, pp. 140-145. https://doi.org/10.1097/MPG.0b013e3181ca4db4
Dotson, Jennifer L. ; Hyams, Jeffrey S. ; Markowitz, James ; Leleiko, Neal S. ; MacK, David R. ; Evans, Jonathan S. ; Pfefferkorn, Marian D. ; Griffiths, Anne M. ; Otley, Anthony R. ; Bousvaros, Athos ; Kugathasan, Subra ; Rosh, Joel R. ; Keljo, David ; Carvalho, Ryan S. ; Tomer, Gitit ; Mamula, Petar ; Kay, Marsha H. ; Kerzner, Benny ; Oliva-Hemker, Maria ; Langton, Christine R. ; Crandall, Wallace. / Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. In: Journal of Pediatric Gastroenterology and Nutrition. 2010 ; Vol. 51, No. 2. pp. 140-145.
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AU - MacK, David R.

AU - Evans, Jonathan S.

AU - Pfefferkorn, Marian D.

AU - Griffiths, Anne M.

AU - Otley, Anthony R.

AU - Bousvaros, Athos

AU - Kugathasan, Subra

AU - Rosh, Joel R.

AU - Keljo, David

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AU - Mamula, Petar

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