Extracellular RNAs: Development as biomarkers of human disease

Joseph F. Quinn, Tushar Patel, David Wong, Saumya Das, Jane E. Freedman, Louise C. Laurent, Bob S. Carter, Fred Hochberg, Kendall Van Keuren-Jensen, Matt Huentelman, Robert Spetzler, M. Yashar S. Kalani, Jorge Arango, P. David Adelson, Howard L. Weiner, Roopali Gandhi, Beatrice Goilav, Chaim Putterman, Julie A. Saugstad

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage,multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

Original languageEnglish (US)
Article number27495
JournalJournal of Extracellular Vesicles
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Biomarkers
  • ERCC
  • ExRNA
  • Extracellular RNA

ASJC Scopus subject areas

  • Histology
  • Cell Biology

Cite this

Quinn, J. F., Patel, T., Wong, D., Das, S., Freedman, J. E., Laurent, L. C., Carter, B. S., Hochberg, F., Van Keuren-Jensen, K., Huentelman, M., Spetzler, R., Kalani, M. Y. S., Arango, J., Adelson, P. D., Weiner, H. L., Gandhi, R., Goilav, B., Putterman, C., & Saugstad, J. A. (2015). Extracellular RNAs: Development as biomarkers of human disease. Journal of Extracellular Vesicles, 4(1), [27495]. https://doi.org/10.3402/jev.v4.27495