Extensive apoptosis in a case of intractable infantile status epilepticus

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalEpilepsy Research
Volume85
Issue number2-3
DOIs
StatePublished - Aug 2009

Fingerprint

Status Epilepticus
Apoptosis
Seizures
Necrosis
Brain
Therapeutics

Keywords

  • Apoptosis
  • Epilepsy surgery
  • Infant
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

@article{12b3a46b5c9d464a8c81c9b4aa08e5b7,
title = "Extensive apoptosis in a case of intractable infantile status epilepticus",
abstract = "A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.",
keywords = "Apoptosis, Epilepsy surgery, Infant, Status epilepticus",
author = "Cherian, {Koshi A.} and Weidenheim, {Karen M.} and Legatt, {Alan D.} and Keivan Shifteh and {Abbott, III}, {Ira Richmond} and Moshe, {Solomon L.}",
year = "2009",
month = "8",
doi = "10.1016/j.eplepsyres.2009.03.009",
language = "English (US)",
volume = "85",
pages = "305--310",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Extensive apoptosis in a case of intractable infantile status epilepticus

AU - Cherian, Koshi A.

AU - Weidenheim, Karen M.

AU - Legatt, Alan D.

AU - Shifteh, Keivan

AU - Abbott, III, Ira Richmond

AU - Moshe, Solomon L.

PY - 2009/8

Y1 - 2009/8

N2 - A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

AB - A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

KW - Apoptosis

KW - Epilepsy surgery

KW - Infant

KW - Status epilepticus

UR - http://www.scopus.com/inward/record.url?scp=67650395282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650395282&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2009.03.009

DO - 10.1016/j.eplepsyres.2009.03.009

M3 - Article

C2 - 19464149

AN - SCOPUS:67650395282

VL - 85

SP - 305

EP - 310

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 2-3

ER -