Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Xin Geng, Alfonso Lavado, Oleg V. Lagutin, Wei Liu, Guillermo Oliver

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.

Original languageEnglish (US)
Pages (from-to)252-257
Number of pages6
JournalGene Expression Patterns
Volume7
Issue number3
DOIs
StatePublished - Jan 2 2007
Externally publishedYes

Keywords

  • Brain development
  • Expression analysis
  • Homeobox
  • Mouse
  • Six3
  • Six3OS

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology

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