Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells

Jin S. Im, Nikos Tapinos, Gue Tae Chae, Petr A. Illarionov, Gurdyal S. Besra, George H. DeVries, Robert L. Modlin, Peter A. Sieling, Anura Rambukkana, Steven A. Porcelli

Research output: Contribution to journalArticle

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Abstract

CD1d-restricted NKT cells expressing invariant TCR α-chains (iNKT cells) produce both proinflammatory and anti-inflammatory cytokines rapidly upon activation, and are believed to play an important role in both host defense and immunoregulation. To address the potential implications of iNKT cell responses for infectious or inflammatory diseases of the nervous system, we investigated the expression of CD1d in human peripheral nerve. We found that CD1d was expressed on the surface of Schwann cells in situ and on primary or immortalized Schwann cell lines in culture. Schwann cells activated iNKT cells in a CD1d-dependent manner in the presence of α-galactosylceramide. Surprisingly, the cytokine production of iNKT cells stimulated by α-galactosylceramide presented by CD1d+ Schwann cells showed a predominance of Th2-associated cytokines such as IL-5 and IL-13 with a marked deficiency of proinflammatory Th1 cytokines such as IFN-α or TNF-α. Our findings suggest a mechanism by which iNKT cells may restrain inflammatory responses in peripheral nerves, and raise the possibility that the expression of CD1d by Schwann cells could be relevant in the pathogenesis of infectious and inflammatory diseases of the peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)5226-5235
Number of pages10
JournalJournal of Immunology
Volume177
Issue number8
StatePublished - Oct 15 2006

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CD1d Antigen
Natural Killer T-Cells
Schwann Cells
Cell Communication
Natural Killer Cells
T-Lymphocytes
Galactosylceramides
Cytokines
Peripheral Nerves
Interleukin-13
Interleukin-5
Peripheral Nervous System
Nervous System Diseases
Communicable Diseases
Anti-Inflammatory Agents
Cell Line

ASJC Scopus subject areas

  • Immunology

Cite this

Im, J. S., Tapinos, N., Chae, G. T., Illarionov, P. A., Besra, G. S., DeVries, G. H., ... Porcelli, S. A. (2006). Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells. Journal of Immunology, 177(8), 5226-5235.

Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells. / Im, Jin S.; Tapinos, Nikos; Chae, Gue Tae; Illarionov, Petr A.; Besra, Gurdyal S.; DeVries, George H.; Modlin, Robert L.; Sieling, Peter A.; Rambukkana, Anura; Porcelli, Steven A.

In: Journal of Immunology, Vol. 177, No. 8, 15.10.2006, p. 5226-5235.

Research output: Contribution to journalArticle

Im, JS, Tapinos, N, Chae, GT, Illarionov, PA, Besra, GS, DeVries, GH, Modlin, RL, Sieling, PA, Rambukkana, A & Porcelli, SA 2006, 'Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells', Journal of Immunology, vol. 177, no. 8, pp. 5226-5235.
Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH et al. Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells. Journal of Immunology. 2006 Oct 15;177(8):5226-5235.
Im, Jin S. ; Tapinos, Nikos ; Chae, Gue Tae ; Illarionov, Petr A. ; Besra, Gurdyal S. ; DeVries, George H. ; Modlin, Robert L. ; Sieling, Peter A. ; Rambukkana, Anura ; Porcelli, Steven A. / Expression of CD1d molecules by human Schwann cells and potential interactions with immunoregulatory invariant NK T cells. In: Journal of Immunology. 2006 ; Vol. 177, No. 8. pp. 5226-5235.
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