Exposing the role of metals in neurological disorders: a focus on manganese

Hyunjin Kim, Fiona E. Harrison, Michael Aschner, Aaron B. Bowman

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Metals are ubiquitous chemical entities involved in a myriad of biological processes. Despite their integral role in sustaining life, overexposure can lead to deleterious neurological outcomes posing a public health concern. Excess exposure to metals has been associated with aberrant neurodevelopmental and neurodegenerative diseases and prominently contributes to environmental risk for neurological disorders. Here, we use manganese (Mn) to exemplify the gap in our understanding of the mechanisms behind acute metal toxicity and their relationship to chronic toxicity and disease. This challenge frustrates understanding of how individual exposure histories translate into preventing and treating brain diseases from childhood through old age. We discuss ways to enhance the predictive value of preclinical models and define mechanisms of chronic, persistent, and latent neurotoxicity.

Original languageEnglish (US)
Pages (from-to)555-568
Number of pages14
JournalTrends in Molecular Medicine
Volume28
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • acute exposures
  • chronic exposures
  • manganese
  • metals
  • neurodegeneration
  • neurodevelopmental

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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