Exploring the Mechanisms of Action of the Novel Microtubule Inhibitor Vinflunine

Mary Ann Jordan, Susan Band Horwitz, Sharon Lobert, John J. Correia

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Microtubules have been identified as a suitable target for anticancer therapy, primarily based on their biological importance in coordinating chromosomal segregation at mitosis. Two main classes of microtubule-targeted agents, the taxanes and vinca alkaloids, suppress the dynamic behavior of spindle microtubules, inducing mitotic arrest and subsequent apoptotic cell death. Clinical activity of taxanes and first-generation vinca alkaloids in the treatment of solid tumors and hematologic malignancies, respectively, has prompted further research for novel analogs with improved clinical efficacy and safety. Such efforts have led to the development of vinflunine, a bifluorinated vinca alkaloid endowed with unique antitumor properties. Highlighted in this review are the key features of vinflunine that lead to effective suppression of microtubule dynamics and induction of cell death in cancer cells.

Original languageEnglish (US)
JournalSeminars in Oncology
Volume35
Issue numberSUPPL 3
DOIs
StatePublished - Jun 2008

Fingerprint

Vinca Alkaloids
Microtubules
Taxoids
Cell Death
Hematologic Neoplasms
Mitosis
Neoplasms
Safety
vinflunine
Research
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Exploring the Mechanisms of Action of the Novel Microtubule Inhibitor Vinflunine. / Jordan, Mary Ann; Band Horwitz, Susan; Lobert, Sharon; Correia, John J.

In: Seminars in Oncology, Vol. 35, No. SUPPL 3, 06.2008.

Research output: Contribution to journalArticle

Jordan, Mary Ann ; Band Horwitz, Susan ; Lobert, Sharon ; Correia, John J. / Exploring the Mechanisms of Action of the Novel Microtubule Inhibitor Vinflunine. In: Seminars in Oncology. 2008 ; Vol. 35, No. SUPPL 3.
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