Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans

Joshua D. Nosanchuk, Aron Mednick, Li Shi, Arturo Casadevall

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cryptococcus neoformans is a fungal pathogen that survives in diverse environments. To determine whether cages of mice infected with C. neoformans posed an infection risk to animal caregivers, we investigated whether the fungus could be isolated from the bedding or stool of mice infected by intratracheal (i.t.), intravenous (i.v.), or intraperitoneal (i.p.) routes. The bedding of mice infected i.t. was contaminated with C. neoformans. In contrast, no contamination of bedding with C. neoformans was detected in cages of mice infected i.v. or i.p. C. neoformans was not isolated from murine feces. The C. neoformans strain recovered from bedding material was indistinguishable from the infecting strain by biochemical and molecular techniques. This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalContemporary Topics in Laboratory Animal Science
Volume42
Issue number4
Publication statusPublished - Jul 1 2003

    Fingerprint

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this