Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans

Joshua D. Nosanchuk, Aron Mednick, Li Shi, Arturo Casadevall

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cryptococcus neoformans is a fungal pathogen that survives in diverse environments. To determine whether cages of mice infected with C. neoformans posed an infection risk to animal caregivers, we investigated whether the fungus could be isolated from the bedding or stool of mice infected by intratracheal (i.t.), intravenous (i.v.), or intraperitoneal (i.p.) routes. The bedding of mice infected i.t. was contaminated with C. neoformans. In contrast, no contamination of bedding with C. neoformans was detected in cages of mice infected i.v. or i.p. C. neoformans was not isolated from murine feces. The C. neoformans strain recovered from bedding material was indistinguishable from the infecting strain by biochemical and molecular techniques. This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalContemporary Topics in Laboratory Animal Science
Volume42
Issue number4
StatePublished - Jul 1 2003

Fingerprint

Cryptococcus neoformans
mice
Infection
infection
cages
animal technicians
Feces
Caregivers
Fungi
feces
lungs
Lung
fungi
pathogens

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans. / Nosanchuk, Joshua D.; Mednick, Aron; Shi, Li; Casadevall, Arturo.

In: Contemporary Topics in Laboratory Animal Science, Vol. 42, No. 4, 01.07.2003, p. 9-12.

Research output: Contribution to journalArticle

@article{d5e58a6322dd4a12bff19207f5a9a75b,
title = "Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans",
abstract = "Cryptococcus neoformans is a fungal pathogen that survives in diverse environments. To determine whether cages of mice infected with C. neoformans posed an infection risk to animal caregivers, we investigated whether the fungus could be isolated from the bedding or stool of mice infected by intratracheal (i.t.), intravenous (i.v.), or intraperitoneal (i.p.) routes. The bedding of mice infected i.t. was contaminated with C. neoformans. In contrast, no contamination of bedding with C. neoformans was detected in cages of mice infected i.v. or i.p. C. neoformans was not isolated from murine feces. The C. neoformans strain recovered from bedding material was indistinguishable from the infecting strain by biochemical and molecular techniques. This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection.",
author = "Nosanchuk, {Joshua D.} and Aron Mednick and Li Shi and Arturo Casadevall",
year = "2003",
month = "7",
day = "1",
language = "English (US)",
volume = "42",
pages = "9--12",
journal = "Journal of the American Association for Laboratory Animal Science",
issn = "1559-6109",
publisher = "American Association for Laboratory Animal Science",
number = "4",

}

TY - JOUR

T1 - Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans

AU - Nosanchuk, Joshua D.

AU - Mednick, Aron

AU - Shi, Li

AU - Casadevall, Arturo

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Cryptococcus neoformans is a fungal pathogen that survives in diverse environments. To determine whether cages of mice infected with C. neoformans posed an infection risk to animal caregivers, we investigated whether the fungus could be isolated from the bedding or stool of mice infected by intratracheal (i.t.), intravenous (i.v.), or intraperitoneal (i.p.) routes. The bedding of mice infected i.t. was contaminated with C. neoformans. In contrast, no contamination of bedding with C. neoformans was detected in cages of mice infected i.v. or i.p. C. neoformans was not isolated from murine feces. The C. neoformans strain recovered from bedding material was indistinguishable from the infecting strain by biochemical and molecular techniques. This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection.

AB - Cryptococcus neoformans is a fungal pathogen that survives in diverse environments. To determine whether cages of mice infected with C. neoformans posed an infection risk to animal caregivers, we investigated whether the fungus could be isolated from the bedding or stool of mice infected by intratracheal (i.t.), intravenous (i.v.), or intraperitoneal (i.p.) routes. The bedding of mice infected i.t. was contaminated with C. neoformans. In contrast, no contamination of bedding with C. neoformans was detected in cages of mice infected i.v. or i.p. C. neoformans was not isolated from murine feces. The C. neoformans strain recovered from bedding material was indistinguishable from the infecting strain by biochemical and molecular techniques. This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection.

UR - http://www.scopus.com/inward/record.url?scp=0042922650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042922650&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 9

EP - 12

JO - Journal of the American Association for Laboratory Animal Science

JF - Journal of the American Association for Laboratory Animal Science

SN - 1559-6109

IS - 4

ER -