Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors

Krzysztof W. Selmaj, Cedric S. Raine, B. H. Waksman, C. Nathan, M. Sporn, K. J. Tracey, H. Wei, K. R. Mannogue, K. Selmaj, C. S. Raine, K. Selmaj, C. S. Raine, M. Farooq, K. Selmaj, M. Farooq, W. T. Norton, K. Selmaj, C. S. Raine, B. Cannella, C. F. BrosnanJ. B. Peter, F. N. Boctor, W. W. Tourtellotte, D. M. Franciotta, L. M E Grimaldi, G. V. Martino, S. L. Hauser, T. H. Doolittle, R. Lincoln, R. H. Brown, C. A. Dinarello, M. K. Sharief, R. Hentges, J. Beck, L. Rondol, L. Calinol, K. Selmaj, C. S. Raines, A. H. Cross, N. H. Ruddle, C. M. Bergman, M. L. McGrath, C. Teuscher, W. F. Hickey, R. Korngold, P. Seckinger, S. Idaaz, J. M. Dayer, T. Kohno, M. T. Brewer, S. L. Baker, K. Selmaj, W. Papierz, A. Glabinski, T. Kohno, D. E. Cavender, D. Edelbaum, M. Ziff, D. M. Barten, N. H. Ruddle, R. J. Hackett, L. S. Davis, P. E. Lipsky, B. K. Brightman, H. Fan

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a demyelinating disease in which an inflammatory cell infiltrate represents a characteristic pathologic feature of active lesions within the CNS.The possibility has been raised that cell-mediated immune mechanisms orchestrate the pathogenesis of MS. Cytokines play a particularly important role in cellular immune mechanisms. These soluble glycoproteins, nonimmunoglobulin in nature, act nonenzymatically to regulate immune cell function. A unique family of cytokines, the tumor necrosis factors (TNFs), demonstrate immunoregulatory activity but are also involved in the effector arm of cellular immune responses. Recently, studies both in vitro and in vivo have suggested a role for TNFs in the pathology of MS. This report summarizes data implicating TNFs in the mechanisms of MS and attempts to apply the anti-TNF approach in the future therapeutic strategy for this disease.

Original languageEnglish (US)
Pages (from-to)S44-S49
JournalNeurology
Volume45
Issue number6
StatePublished - 1995

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Tumor Necrosis Factors
Autoimmune Experimental Encephalomyelitis
Tumor Necrosis Factor Receptors
Immunotherapy
Multiple Sclerosis
Tumor Necrosis Factor-alpha
Antibodies
Cytokines
Demyelinating Diseases
Cellular Immunity
Glycoproteins
Pathology
Cells

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Selmaj, K. W., Raine, C. S., Waksman, B. H., Nathan, C., Sporn, M., Tracey, K. J., ... Fan, H. (1995). Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors. Neurology, 45(6), S44-S49.

Experimental autoimmune encephalomyelitis : Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors. / Selmaj, Krzysztof W.; Raine, Cedric S.; Waksman, B. H.; Nathan, C.; Sporn, M.; Tracey, K. J.; Wei, H.; Mannogue, K. R.; Selmaj, K.; Raine, C. S.; Selmaj, K.; Raine, C. S.; Farooq, M.; Selmaj, K.; Farooq, M.; Norton, W. T.; Selmaj, K.; Raine, C. S.; Cannella, B.; Brosnan, C. F.; Peter, J. B.; Boctor, F. N.; Tourtellotte, W. W.; Franciotta, D. M.; Grimaldi, L. M E; Martino, G. V.; Hauser, S. L.; Doolittle, T. H.; Lincoln, R.; Brown, R. H.; Dinarello, C. A.; Sharief, M. K.; Hentges, R.; Beck, J.; Rondol, L.; Calinol, L.; Selmaj, K.; Raines, C. S.; Cross, A. H.; Ruddle, N. H.; Bergman, C. M.; McGrath, M. L.; Teuscher, C.; Hickey, W. F.; Korngold, R.; Seckinger, P.; Idaaz, S.; Dayer, J. M.; Kohno, T.; Brewer, M. T.; Baker, S. L.; Selmaj, K.; Papierz, W.; Glabinski, A.; Kohno, T.; Cavender, D. E.; Edelbaum, D.; Ziff, M.; Barten, D. M.; Ruddle, N. H.; Hackett, R. J.; Davis, L. S.; Lipsky, P. E.; Brightman, B. K.; Fan, H.

In: Neurology, Vol. 45, No. 6, 1995, p. S44-S49.

Research output: Contribution to journalArticle

Selmaj, KW, Raine, CS, Waksman, BH, Nathan, C, Sporn, M, Tracey, KJ, Wei, H, Mannogue, KR, Selmaj, K, Raine, CS, Selmaj, K, Raine, CS, Farooq, M, Selmaj, K, Farooq, M, Norton, WT, Selmaj, K, Raine, CS, Cannella, B, Brosnan, CF, Peter, JB, Boctor, FN, Tourtellotte, WW, Franciotta, DM, Grimaldi, LME, Martino, GV, Hauser, SL, Doolittle, TH, Lincoln, R, Brown, RH, Dinarello, CA, Sharief, MK, Hentges, R, Beck, J, Rondol, L, Calinol, L, Selmaj, K, Raines, CS, Cross, AH, Ruddle, NH, Bergman, CM, McGrath, ML, Teuscher, C, Hickey, WF, Korngold, R, Seckinger, P, Idaaz, S, Dayer, JM, Kohno, T, Brewer, MT, Baker, SL, Selmaj, K, Papierz, W, Glabinski, A, Kohno, T, Cavender, DE, Edelbaum, D, Ziff, M, Barten, DM, Ruddle, NH, Hackett, RJ, Davis, LS, Lipsky, PE, Brightman, BK & Fan, H 1995, 'Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors', Neurology, vol. 45, no. 6, pp. S44-S49.
Selmaj, Krzysztof W. ; Raine, Cedric S. ; Waksman, B. H. ; Nathan, C. ; Sporn, M. ; Tracey, K. J. ; Wei, H. ; Mannogue, K. R. ; Selmaj, K. ; Raine, C. S. ; Selmaj, K. ; Raine, C. S. ; Farooq, M. ; Selmaj, K. ; Farooq, M. ; Norton, W. T. ; Selmaj, K. ; Raine, C. S. ; Cannella, B. ; Brosnan, C. F. ; Peter, J. B. ; Boctor, F. N. ; Tourtellotte, W. W. ; Franciotta, D. M. ; Grimaldi, L. M E ; Martino, G. V. ; Hauser, S. L. ; Doolittle, T. H. ; Lincoln, R. ; Brown, R. H. ; Dinarello, C. A. ; Sharief, M. K. ; Hentges, R. ; Beck, J. ; Rondol, L. ; Calinol, L. ; Selmaj, K. ; Raines, C. S. ; Cross, A. H. ; Ruddle, N. H. ; Bergman, C. M. ; McGrath, M. L. ; Teuscher, C. ; Hickey, W. F. ; Korngold, R. ; Seckinger, P. ; Idaaz, S. ; Dayer, J. M. ; Kohno, T. ; Brewer, M. T. ; Baker, S. L. ; Selmaj, K. ; Papierz, W. ; Glabinski, A. ; Kohno, T. ; Cavender, D. E. ; Edelbaum, D. ; Ziff, M. ; Barten, D. M. ; Ruddle, N. H. ; Hackett, R. J. ; Davis, L. S. ; Lipsky, P. E. ; Brightman, B. K. ; Fan, H. / Experimental autoimmune encephalomyelitis : Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors. In: Neurology. 1995 ; Vol. 45, No. 6. pp. S44-S49.
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title = "Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors",
abstract = "Multiple sclerosis (MS) is a demyelinating disease in which an inflammatory cell infiltrate represents a characteristic pathologic feature of active lesions within the CNS.The possibility has been raised that cell-mediated immune mechanisms orchestrate the pathogenesis of MS. Cytokines play a particularly important role in cellular immune mechanisms. These soluble glycoproteins, nonimmunoglobulin in nature, act nonenzymatically to regulate immune cell function. A unique family of cytokines, the tumor necrosis factors (TNFs), demonstrate immunoregulatory activity but are also involved in the effector arm of cellular immune responses. Recently, studies both in vitro and in vivo have suggested a role for TNFs in the pathology of MS. This report summarizes data implicating TNFs in the mechanisms of MS and attempts to apply the anti-TNF approach in the future therapeutic strategy for this disease.",
author = "Selmaj, {Krzysztof W.} and Raine, {Cedric S.} and Waksman, {B. H.} and C. Nathan and M. Sporn and Tracey, {K. J.} and H. Wei and Mannogue, {K. R.} and K. Selmaj and Raine, {C. S.} and K. Selmaj and Raine, {C. S.} and M. Farooq and K. Selmaj and M. Farooq and Norton, {W. T.} and K. Selmaj and Raine, {C. S.} and B. Cannella and Brosnan, {C. F.} and Peter, {J. B.} and Boctor, {F. N.} and Tourtellotte, {W. W.} and Franciotta, {D. M.} and Grimaldi, {L. M E} and Martino, {G. V.} and Hauser, {S. L.} and Doolittle, {T. H.} and R. Lincoln and Brown, {R. H.} and Dinarello, {C. A.} and Sharief, {M. K.} and R. Hentges and J. Beck and L. Rondol and L. Calinol and K. Selmaj and Raines, {C. S.} and Cross, {A. H.} and Ruddle, {N. H.} and Bergman, {C. M.} and McGrath, {M. L.} and C. Teuscher and Hickey, {W. F.} and R. Korngold and P. Seckinger and S. Idaaz and Dayer, {J. M.} and T. Kohno and Brewer, {M. T.} and Baker, {S. L.} and K. Selmaj and W. Papierz and A. Glabinski and T. Kohno and Cavender, {D. E.} and D. Edelbaum and M. Ziff and Barten, {D. M.} and Ruddle, {N. H.} and Hackett, {R. J.} and Davis, {L. S.} and Lipsky, {P. E.} and Brightman, {B. K.} and H. Fan",
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language = "English (US)",
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pages = "S44--S49",
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TY - JOUR

T1 - Experimental autoimmune encephalomyelitis

T2 - Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors

AU - Selmaj, Krzysztof W.

AU - Raine, Cedric S.

AU - Waksman, B. H.

AU - Nathan, C.

AU - Sporn, M.

AU - Tracey, K. J.

AU - Wei, H.

AU - Mannogue, K. R.

AU - Selmaj, K.

AU - Raine, C. S.

AU - Selmaj, K.

AU - Raine, C. S.

AU - Farooq, M.

AU - Selmaj, K.

AU - Farooq, M.

AU - Norton, W. T.

AU - Selmaj, K.

AU - Raine, C. S.

AU - Cannella, B.

AU - Brosnan, C. F.

AU - Peter, J. B.

AU - Boctor, F. N.

AU - Tourtellotte, W. W.

AU - Franciotta, D. M.

AU - Grimaldi, L. M E

AU - Martino, G. V.

AU - Hauser, S. L.

AU - Doolittle, T. H.

AU - Lincoln, R.

AU - Brown, R. H.

AU - Dinarello, C. A.

AU - Sharief, M. K.

AU - Hentges, R.

AU - Beck, J.

AU - Rondol, L.

AU - Calinol, L.

AU - Selmaj, K.

AU - Raines, C. S.

AU - Cross, A. H.

AU - Ruddle, N. H.

AU - Bergman, C. M.

AU - McGrath, M. L.

AU - Teuscher, C.

AU - Hickey, W. F.

AU - Korngold, R.

AU - Seckinger, P.

AU - Idaaz, S.

AU - Dayer, J. M.

AU - Kohno, T.

AU - Brewer, M. T.

AU - Baker, S. L.

AU - Selmaj, K.

AU - Papierz, W.

AU - Glabinski, A.

AU - Kohno, T.

AU - Cavender, D. E.

AU - Edelbaum, D.

AU - Ziff, M.

AU - Barten, D. M.

AU - Ruddle, N. H.

AU - Hackett, R. J.

AU - Davis, L. S.

AU - Lipsky, P. E.

AU - Brightman, B. K.

AU - Fan, H.

PY - 1995

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C2 - 7783912

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