Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain

C. Colantuoni, J. Schwenker, J. McCarthy, P. Rada, B. Ladenheim, J. L. Cadet, Gary J. Schwartz, T. H. Moran, B. G. Hoebel

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose solution with chow for 12 h followed by 12 h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-I receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-I receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-I and mu-I receptors much like some drugs of abuse.

Original languageEnglish (US)
Pages (from-to)3549-3552
Number of pages4
JournalNeuroReport
Volume12
Issue number16
StatePublished - Nov 16 2001
Externally publishedYes

Fingerprint

mu Opioid Receptor
Street Drugs
Dopamine
Glucose
Food Deprivation
Dopamine Plasma Membrane Transport Proteins
Locus Coeruleus
Gyrus Cinguli
Brain
Mesencephalon
Substance-Related Disorders
Hippocampus
Food
dopamine-I receptor

Keywords

  • Accumbens
  • Binge
  • D-I
  • Dopamine
  • Glucose
  • Mu
  • Opioid
  • Rat
  • Receptor
  • Sugar

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J. L., ... Hoebel, B. G. (2001). Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. NeuroReport, 12(16), 3549-3552.

Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. / Colantuoni, C.; Schwenker, J.; McCarthy, J.; Rada, P.; Ladenheim, B.; Cadet, J. L.; Schwartz, Gary J.; Moran, T. H.; Hoebel, B. G.

In: NeuroReport, Vol. 12, No. 16, 16.11.2001, p. 3549-3552.

Research output: Contribution to journalArticle

Colantuoni, C, Schwenker, J, McCarthy, J, Rada, P, Ladenheim, B, Cadet, JL, Schwartz, GJ, Moran, TH & Hoebel, BG 2001, 'Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain', NeuroReport, vol. 12, no. 16, pp. 3549-3552.
Colantuoni C, Schwenker J, McCarthy J, Rada P, Ladenheim B, Cadet JL et al. Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. NeuroReport. 2001 Nov 16;12(16):3549-3552.
Colantuoni, C. ; Schwenker, J. ; McCarthy, J. ; Rada, P. ; Ladenheim, B. ; Cadet, J. L. ; Schwartz, Gary J. ; Moran, T. H. ; Hoebel, B. G. / Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. In: NeuroReport. 2001 ; Vol. 12, No. 16. pp. 3549-3552.
@article{3b5dde513ef0475882e5e3d8d5ffed70,
title = "Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain",
abstract = "Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25{\%} glucose solution with chow for 12 h followed by 12 h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-I receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-I receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-I and mu-I receptors much like some drugs of abuse.",
keywords = "Accumbens, Binge, D-I, Dopamine, Glucose, Mu, Opioid, Rat, Receptor, Sugar",
author = "C. Colantuoni and J. Schwenker and J. McCarthy and P. Rada and B. Ladenheim and Cadet, {J. L.} and Schwartz, {Gary J.} and Moran, {T. H.} and Hoebel, {B. G.}",
year = "2001",
month = "11",
day = "16",
language = "English (US)",
volume = "12",
pages = "3549--3552",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "16",

}

TY - JOUR

T1 - Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain

AU - Colantuoni, C.

AU - Schwenker, J.

AU - McCarthy, J.

AU - Rada, P.

AU - Ladenheim, B.

AU - Cadet, J. L.

AU - Schwartz, Gary J.

AU - Moran, T. H.

AU - Hoebel, B. G.

PY - 2001/11/16

Y1 - 2001/11/16

N2 - Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose solution with chow for 12 h followed by 12 h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-I receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-I receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-I and mu-I receptors much like some drugs of abuse.

AB - Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose solution with chow for 12 h followed by 12 h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-I receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-I receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-I and mu-I receptors much like some drugs of abuse.

KW - Accumbens

KW - Binge

KW - D-I

KW - Dopamine

KW - Glucose

KW - Mu

KW - Opioid

KW - Rat

KW - Receptor

KW - Sugar

UR - http://www.scopus.com/inward/record.url?scp=0035900374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035900374&partnerID=8YFLogxK

M3 - Article

C2 - 11733709

AN - SCOPUS:0035900374

VL - 12

SP - 3549

EP - 3552

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 16

ER -